摘要
目的探讨柴胡桂枝干姜汤联合放化疗对宫颈癌患者的临床疗效、中医证候积分、细胞免疫功能、生存质量及不良反应的影响。方法选取2019年5月—2021年12月医院收治的70例宫颈癌患者作为研究对象,根据治疗方式将其分为对照组(35例,放化疗治疗)和观察组(35例,柴胡桂枝干姜汤+放化疗治疗)。比较两组临床疗效及治疗前后中医证候积分、细胞免疫功能、生存质量及不良反应的差异。结果观察组的治疗总有效率为60.00%,高于对照组34.28%(P<0.05)。治疗后,两组的纳差便溏、腰酸汗出、心烦口苦评分均低于治疗前,且观察组低于对照组(P<0.05)。治疗后,两组的CD^(+)_(4)、Treg、NK细胞水平均高于治疗前,CD^(+)_(8)水平均低于治疗前,且观察组优于对照组(P<0.05)。治疗后,两组的NRS评分低于治疗前,FACT-G评分高于治疗前,且观察组优于对照组(P<0.05)。观察组骨髓抑制、呕吐腹泻、肝肾功能异常、中性粒细胞下降的发生率均低于对照组,发生程度均轻于对照组(P<0.05)。结论柴胡桂枝干姜汤加减联合放化疗治疗宫颈癌在提高临床疗效、改善患者中医证候积分、改善免疫功能、提高生存质量及减轻不良反应等方面均优于单纯放化疗组,值得临床推广和应用。
Objective To investigate the clinical efficacy,TCM syndrome scores,cellular immune function,quality of life and side effects of Chaihu Guizhi Ganjiang Decoction(柴胡桂枝干姜汤)combined with chemoradiotherapy in patients with cervical cancer.Methods Seventy patients with cervical cancer treated in the hospital from May 2019 to December 2021 were selected as the research objects.According to the treatment methods,they were divided into the control group(35 cases,treated with chemo-radiotherapy)and the observation group(35 cases,treated with Chaihu Guizhi Ganjiang Decoction and chemoradiotherapy).The clinical efficacy,TCM syndrome score,cellular immune function,quality of life and toxicity were compared between the two groups before and after treatment.Results The total effective rate of the observation group was 60.00%,which was higher than that of control group(34.28%)(P<0.05).After treatment,the scores of poor appetite,loose stool,sore waist,sweating,restlessness and bitter taste in the two groups were lower than those before treatment,and the scores of the observation group were lower than those of the control group(P<0.05).After treatment,the levels of CD^(+)_(4),Treg and NK cells in the two groups were higher than those before treatment,and the levels of CD^(+)_(8)were lower than those before treatment,and the levels of the observation group were better than those of the control group(P<0.05).After treatment,the numerical rating scale(NRS)score of the two groups was lower than that before treatment,the functional assessment of cancer therapy-generic scale(FACT-G)score was higher than that before treatment,and the scores of the observation group were better than those of the control group(P<0.05).The inci-dence of myelosuppression,vomiting and diarrhea,abnormal liver and kidney function and neutropenia in the observation group was lower than that in the control group,and the degree of occurrence was lighter than that in the control group(P<0.05).Conclusion Chaihu Guizhi Ganjiang Decoction combined with chemoradiotherapy in the treatment of cervical cancer can improve the clinical efficacy,the TCM syndrome scores,the immune function and the quality of life and reduce the side effects,which is worthy of clinical promotion and application.
作者
付金平
赵沁慧
陈惠
张文君
刘巧玲
潘巍
FU Jinping;ZHAO Qinhui;CHEN Hui;ZHANG Wenjun;LIU Qiaoing;PAN Wei(The Affiliated Jiangning Hospital of Nanjing Medical University,Nanjing 211100,Jiangsu,China)
出处
《中华中医药学刊》
CAS
北大核心
2024年第9期100-103,共4页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金青年科学基金项目(82002881)。
关键词
宫颈癌
柴胡桂枝干姜汤
放化疗
免疫功能
生存质量
不良反应
cervical cancer
Chaihu Guizhi Ganjiang Decoction(柴胡桂枝干姜汤)
radiation and chemotherapy
immune function
quality of life
adverse reaction
