摘要
抑郁症因逐年升高的发病率已经受到了医学界的广泛关注。抑郁症发病因素极其复杂,因此在进行相关实验时构建相应抑郁症模型成为实验关键步骤。本文主要介绍常见小鼠抑郁症模型的构建方法,例如慢性不可预见性温和刺激模型,特殊药物所致抑郁模型,生命早期应激模型等,以及相关评估抑郁程度的行为学实验,例如强迫游泳实验、蔗糖偏好实验、喷溅实验等,为相关研究人员提供实验思路及方法。
Depression has received widespread attention from the medical community due to its increasing incidence year by year.The factors of depression are extremely complex,so the construction of depression models has become a key step when conducting related experiments.This paper mainly introduces the construction method of common mouse depression models,such as chronic unpredictable mild stimulus model,special drug-induced depression model,early life stress model,etc.,and related behavioural experiments to assess the degree of depression,such as forced swimming experiment,sucrose preference experiment,splashing experiment,etc.,which provide relevant researchers with experimental ideas and method.
作者
王金辉
张勇
董伟韬
张全伟
WANG Jinhui;ZHANG Yong;DONG Weitao;ZHANG Quanwei(College of Veterinary Medicine,Gansu Agricultural University,Lanzhou 730000,China)
出处
《实验动物科学》
2024年第4期75-79,共5页
Laboratory Animal Science
关键词
抑郁症
动物模型
行为学评估
depression
animal models
behavioral assessment
