摘要
目的:观察西帕依固龈液联合盐酸米诺环素、牙周基础治疗用于牙周炎患者的效果。方法:选取2022年10月至2023年10月福州市鼓楼区亚华口腔收治的80例牙周炎患者进行前瞻性研究,按照随机数字表法分为研究组与对照组各40例。对照组采用盐酸米诺环素治疗联合牙周基础治疗,研究组在对照组基础上联用西帕依固龈液治疗,比较两组血清炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-1β、IL-6]水平、疼痛视觉模拟评分法(VAS)评分、咀嚼效率、牙周指标[牙龈指数(GI)、菌斑指数(PLI)]水平和简化牙本质敏感影响程度量表(DHEQ-15)评分。结果:治疗后,研究组咀嚼效率高于对照组,血清IL-1β、TNF-α、IL-6等炎性因子水平和PLI、GI、VAS、DHEQ-15评分低于对照组,差异均有统计学意义(P<0.05)。结论:西帕依固龈液联合盐酸米诺环素、牙周基础治疗用于牙周炎患者可提高咀嚼效率,降低血清炎性因子水平、牙周指标水平、VAS评分和DHEQ-15评分,效果优于盐酸米诺环素联合牙周基础治疗。
Objective:To observe effects of Xipayi mouth rinse combined with Minocycline hydrochloride and periodental nonsurgical treatment on patients with periodontitis.Methods:From October 2022 to October 2023,80 patients with periodontitis admitted to Yahua Stomatology Hospital of Gulou District of Fuzhou city were selected for the prospective study.According to the random number table method,they were divided into study group and control group,40 cases in each group.The control group was treated with Minocycline hydrochloride combined with periodental non-surgical treatment,while the study group was treated with Xipayi mouth rinse on the basis of that of the control group.The levels of serum inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin(IL)-1β,IL-6],the pain visual analogue scale(VAS)score,the masticatory efficiency,the periodontal index[gingival index(GI),plaque index(PLI)]levels,and the simplified dentine hypersensitivity experience questionnaire(DHEQ-15)score were compared between the two groups.Results:After the treatment,the masticatory efficiency of the study group were higher than those of the control group;the levels of serum inflammatory factors such as IL-1β,TNF-αand IL-6 and periodontal indexes such as PLI,GI,the VAS scores and the DHEQ-15 scores were lower than those of the control group;and the differences were statistically significant(P<0.05).Conclusions:Xipayi mouth rinse combined with Minocycline hydrochloride and periodental non-surgical treatment for the patients with periodontitis can improve their masticatory efficiencies and reduce the serum inflammatory factor levels,periodontal index levels,VAS scores and DHEQ-15 scores.Moreover,it is superior to Minocycline hydrochloride combined with periodental non-surgical treatment.
作者
陈华汇
王嵩
林杨浩
CHEN Huahui;WANG Song;LIN Yanghao(Department of Stomatology of Yahua Stomatology Hospital of Gulou District of Fuzhou City,Fuzhou 350000 Fujian,China;Stomatology Department of Fuzhou Gulou Meijielong Dental Clinic,Fuzhou 350001 Fujian,China)
出处
《中国民康医学》
2024年第18期64-66,共3页
Medical Journal of Chinese People’s Health
关键词
西帕依固龈液
盐酸米诺环素
牙周炎
炎性因子
疼痛
Xipayi mouth rinse
Minocycline hydrochloride
Periodontitis
Inflammatory factor
Pain
