摘要
目的:探讨老年伴焦虑症状的抑郁症采用丁螺环酮联合度洛西汀治疗的临床效果。方法:依据随机数字表法将许昌市建安医院2022年1月—2024年1月收治的85例老年伴焦虑症状的抑郁症患者分为对照组(n=42,度洛西汀)和观察组(n=43,度洛西汀+丁螺环酮),两组均持续治疗8周。比较两组焦虑症状、抑郁症状、血清5-羟色胺水平、去甲肾上腺素水平、睡眠质量及不良反应。结果:治疗8周,观察组汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)、匹兹堡睡眠质量指数(PSQI)评分均低于对照组,血清5-羟色胺、去甲肾上腺素水平均高于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:丁螺环酮联合度洛西汀治疗可减轻老年伴焦虑症状的抑郁症患者的焦虑、抑郁症状,改善血清5-羟色胺、去甲肾上腺素水平,提高睡眠质量,且未明显增加不良反应。
Objective:To explore the clinical effect of buspirone combined with duloxetine in the treatment of senile depression with anxiety symptoms.Methods:According to the random number table method,85 elderly depression patients with anxiety symptoms admitted to Xuchang Jian’an Hospital from January 2022 to January 2024 were divided into control group(n=42,duloxetine)and observation group(n=43,duloxetine+buspirone).Both groups were treated for 8 weeks.The anxiety symptoms,depression symptoms,serum 5-hydroxytryptamine level,norepinephrine level,sleep quality and adverse reactions were compared between the two groups.Results:After 8 weeks of treatment,the scores of Hamilton Anxiety Scale(HAMA),Hamilton Depression Scale(HAMD)and Pittsburgh Sleep Quality Index(PSQI)in the observation group were lower than those in the control group,while the serum levels of serotonin and norepinephrine were higher than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combination of buspirone and duloxetine can alleviate anxiety and depression symptoms in elderly patients with depression accompanied by anxiety symptoms,improve serum serotonin and norepinephrine levels,enhance sleep quality,and do not significantly increase adverse reactions.
作者
李想
寇建华
LI Xiang;KOU Jianhua(Xuchang Jian’an Hospital,Xuchang 461000,Henan,China)
出处
《中国药物滥用防治杂志》
CAS
2024年第8期1393-1396,共4页
Chinese Journal of Drug Abuse Prevention and Treatment
基金
河南省卫生健康委课题(编号:2021108)。
