摘要
随着玻璃化冷冻技术的改进,冻融胚胎移植(frozen-thawed embryo transfer,FET)技术在预防卵巢过度刺激综合征、降低异位妊娠率以及提高累积妊娠率等方面发挥了重要作用。FET在辅助生殖助孕过程中周期占比逐年上升,已成为辅助生殖技术的重要组成部分。FET的妊娠结局受多种因素的影响,主要包括年龄、胚胎质量、子宫内膜厚度、子宫内膜准备方案、DNA碎片化和Y染色体微缺失等。其中年龄、胚胎质量、内膜容受性是决定FET治疗成功与否的关键因素,直接影响胚胎发育、着床和妊娠成功率。因此,识别FET妊娠结局的影响因素,并采取更精准、个体化、有针对性的预防措施以提高妊娠率已经成为研究热点。综述FET妊娠结局的相关影响因素,旨在为临床医疗决策提供科学依据。
With the advancement of vitrification freezing technology,frozen-thawed embryo transfer(FET)plays a crucial role in assisted reproductive technology by preventing ovarian hyperstimulation syndrome,reducing ectopic pregnancy rates,and enhancing cumulative pregnancy rates.The proportion of FET cycles in assisted reproduction has been increasing annually,establishing FET as a key component of reproductive technologies.The outcome of FET pregnancies is influenced by various factors,including age,embryo quality,endometrial thickness,endometrial preparation protocols,DNA fragmentation,and Y chromosome microdeletions.Age,embryo quality,and endometrial receptivity are pivotal factors determining the success of FET treatments,directly impacting embryo development,implantation,and pregnancy success rates.Therefore,identifying the influencing factors of FET pregnancy outcome,so as to implement more precise,personalized and targeted prevention to improve pregnancy rates,has become a research hotspot.This review aims to summarize the relevant factors affecting the outcome of FET pregnancies,providing a reference for clinical decision.
作者
罗莎莎
王德婧(审校)
LUO Sha-sha;WANG De-jing(Department of Nursing,Affiliated Hospital of Zunyi Medical University,School of Nursing of Zunyi Medical University,Zunyi 563000,Guizhou Province,China;Department of Reproductive Medicine,Affiliated Hospital of Zunyi Medical University,Department of Obstetrics and Gynecology,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,Guizhou Province,China)
出处
《国际生殖健康／计划生育杂志》
CAS
2024年第5期420-424,共5页
Journal of International Reproductive Health/Family Planning
关键词
冻融胚胎移植
生殖技术
辅助
妊娠结局
影响因素
妊娠率
Frozen-thawed embryo transfer
Reproductive techniques,assisted
Pregnancy outcome
Influencing factors
Pregnancy rate
