摘要
目的:分析红细胞悬液与去白红细胞悬液输血治疗重型地中海贫血的临床效果。方法:选取2020年1月—2023年6月于海丰县彭湃纪念医院进行治疗的重型地中海贫血患者60例。依次对患者进行编号,单号患者分为红细胞组(n=30),接受红细胞悬液输血治疗,双号患者分为去白红细胞组(n=30),接受去白红细胞悬液输血治疗。比较两组临床疗效、D-二聚体(D-D)水平、血浆纤维蛋白原(FIB)水平、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、不良反应发生情况。结果:去白红细胞组临床治疗总有效率为100.00%,红细胞组临床治疗总有效率为86.67%,去白红细胞组临床治疗总有效率高于红细胞组(P<0.05)。治疗前,两组D-D、FIB水平比较,差异无统计学意义(P>0.05);治疗后,去白红细胞组D-D水平低于红细胞组(P<0.05),FIB水平高于红细胞组(P<0.05)。治疗前,两组PT、APTT、TT比较,差异无统计学意义(P>0.05);治疗后,去白红细胞组PT、APTT、TT均长于红细胞组(P<0.05)。去白红细胞组过敏反应、紫癜、发热、皮疹等不良反应总发生率为6.67%,红细胞组为26.67%,去白红细胞组低于红细胞组(P<0.05)。结论:相比于红细胞悬液输血治疗,去白红细胞悬液输血治疗可提高重型地中海贫血患者临床治疗效果,改善纤溶功能和凝血功能,减少不良反应发生风险。
Objective To explore the clinical effect of red blood cell suspension and leucocyte suspension transfusion on patients with severe thalassemia.Methods A total of 60 patients with severe thalassemia treated in the hospital from January 2020 to June 2023 were selected as the research object.The patients were numbered in turn.Patients with odd numbers were divided into red blood cell group(n=30)and received red blood cell suspension transfusion,while patients with even numbers were divided into leukocyte-depleted red blood cell group(n=30)and received leukocyte-depleted red blood cell suspension transfusion.The clinical efficacy,D-dimer(D-D)level,plasma fibrinogen(FIB)level,prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT)and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of clinical treatment was 100.00%in leucocyte group and 86.67%in erythrocyte group,which was higher than that in erythrocyte group(P<0.05).Before treatment,there was no significant difference in the levels of D-D and FIB were between the two groups(P>0.05).After treatment,the level of D-D in leucocyte group was lower than that in erythrocyte group(P<0.05),and the level of FIB in leucocyte group was higher than that in erythrocyte group(P<0.05).Before treatment,there was no significant difference in the indexes of PT,APTT and TT between the two groups(P>0.05).After treatment,the indexes of PT,APTT and TT in the leucocyte-depleted group were longer than those in the erythrocyte group(P<0.05).The total incidence of allergic reaction,purpura,fever,rash and other adverse reactions was 6.67%in the leucocyte group,and 26.67%in the control group,which was lower than that in the erythrocytic group(P<0.05).Conclusions Compared with red blood cell suspension transfusion therapy,leucocyte suspension transfusion therapy can improve the clinical therapeutic effect of patients with severe thalassemia,improve fibrinolytic function and coagulation function,and reduce the risk of adverse reactions.
作者
王佳义
WANG Jiayi(Department of Blood Transfusion,Pengpai Memorial Hospital,Haifeng County,Shanwei,Guangdong 516400,China)
出处
《医药前沿》
2024年第26期18-20,共3页
Journal of Frontiers of Medicine
关键词
红细胞悬液
去白红细胞悬液输血
重型地中海贫血
疗效
Red blood cell suspension
Leukocyte suspension transfusion
Severe thalassemia
Curative effect
