摘要
目的探讨抑郁症患者应用逍遥散联合化痰通络汤加盐酸度洛西汀片的治疗效果。方法以2021年1月至2023年5月至开封市第五人民医院就诊的62例抑郁症患者为研究对象,均符合临床抑郁症诊断标准,年龄不低于18岁,将2022年7月前入院的给予盐酸度洛西汀片治疗,31例患者纳入对照组,将2022年7月后入院的给予逍遥散合化痰通络汤加盐酸度洛西汀片治疗,31例患者纳入观察组,对比两组治疗效果。结果观察组治疗总有效率(93.55%)显著高于对照组(74.19%)(P<0.05);治疗前两组中医症候积分、汉密尔顿抑郁量表(HAMD)量表得分、应用症状自评量表(SCL-90)躯体化部分得分、匹兹堡睡眠质量量表(PSQI)得分以及白介素-4(IL-4)、白介素-6(IL-6)、肿瘤坏死因子(TNF-α)、脑源性神经营养因子(BDNF)、成纤维细胞生长因子22(FGF-22)水平对比均无显著差异(P>0.05);治疗后观察组中医症候积分、HAMD、SCL-90、PSQI量表得分以及IL-6、TNF-α、BDNF、FGF-22水平较低,IL-4水平较高,对比差异有统计学意义(P<0.05)。结论临床治疗抑郁症患者应用逍遥散合化痰通络汤加盐酸度洛西汀片效果显著,能够有效调节机体炎症反应与生化指标,改善临床症状,提高睡眠质量。
Objective To explore the therapeutic effect of Xiaoyao powder combined with Huatan Tongluo decoction and duloxetine hydrochloride tablets in patients with depression.Methods A total of 62 patients with depression who visited the Fifth People's Hospital of Kaifeng City from January 2021 to May 2023 were selected as the study objects.All of them met the diagnostic criteria for clinical depression and were at least 18 years old.31 patients hospitalized before July 2022 who were treated with duloxetine hydrochloride tablets were included in the control group,and 31 patients hospitalized after July 2022 who were treated with Xiaoyao powder,Huatan Tongluo decoction plus duloxetine hydrochloride tablets were included in the observation group.The therapeutic effect of the two groups was compared.Results The total effective rate of observation group(93.55%)was significantly higher than that of control group(74.19%)(P<0.05).Before treatment,there were no significant differences in the scores of traditional Chinese medicine syndromes,hamilton depression scale(HAMD),the somatization part of the symptom checklist-90(SCL-90),the pittsburgh sleep quality index(PSQI),and the levels of interleukin-4(IL-4),interleukin-6(IL-6),tumor necrosis factor(TNF-α),brain-derived neurotrophic factor(BDNF),and fibroblast growth factor 22(FGF-22)between the two groups(P>0.05).After treatment,TCM syndrome score,HAMD,SCL-90,PSQI score,IL-6,TNF-α,BDNF,FGF-22 level and IL-4 level were lower in observation group,and the difference was statistically significant(P<0.05).Conclusion The clinical treatment of depression patients with Xiaoyao powder Huatan Tongluo decoction combined with duloxetine hydrochloride tablets has significant effects,can effectively regulate the body's inflammatory response and biochemical indicators and clinical symptoms and sleep quality.
作者
徐春朝
高超
XU Chun-chao;GAO Chao(Department of Integrative Medicine,The Fifth People's Hospital of Kaifeng,Kaifeng,Henan 475000,China;Department of Psychiatry,the Fourth People's Hospital of Nanyang City,Nanyang,Henan 473000,China)
出处
《医药论坛杂志》
2024年第14期1549-1553,共5页
Journal of Medical Forum
基金
河南省医学科技攻关计划联合共建项目(LHGJ20200901)。
关键词
抑郁症
逍遥散
化痰通络汤
盐酸度洛西汀片
临床症状
量表
Depression
Xiaoyao powder
Huatan Tongluo decoction
Duloxetine hydrochloride tablets
Clinical symptoms
Scale
