摘要
抗癌肽是含有5~50个氨基酸的小型阳离子肽。抗癌肽具有独特的抗癌机制,如破坏细胞膜、诱导细胞凋亡、抑制血管生成、免疫调节、诱导DNA损伤和抑制细胞增殖。抗癌肽在治疗癌症方面具有巨大的潜力,但在临床上应用尚未成熟,仍处于临床试验阶段。总结了抗癌肽的抗肿瘤作用机制、临床应用情况,以期为抗癌肽开发为新型高效低毒的抗癌药物提供思路。
Anticancer peptides are small cationic peptides containing 5 to 50 amino acids.Anticancer peptides have unique anticancer mechanisms,such as destroying cell membranes,inducing apoptosis,inhibiting angiogenesis,immune regulation,inducing DNA damage,and inhibiting cell proliferation.Anticancer peptides have great potential in treatment of cancer,but their clinical application is not yet mature and is still in the clinical trial stage.This article summarizes the anti-tumor mechanism and clinical application of anticancer peptides,in order to provide ideas for the development of anticancer peptides as new highly efficient and low toxicity anticancer drugs.
作者
苏祖恒
梅先林
吴科锋
陈起周
余华军
张海涛
罗辉
SU Zuheng;MEI Xianlin;WU Kefeng;CHEN Qizhou;YU Huajun;ZHANG Haitao;LUO Hui(Guangdong Medical University,Zhanjiang 524001,China;The Marine Biomedical Research Institute of Guangdong Zhanjiang,Zhanjiang 524001,China;The Key Lab of Zhanjiang of Marine Microbial Resources in the Beibu Gulf Rim,Guangdong Medical University,Zhanjiang524023,China)
出处
《现代药物与临床》
CAS
2024年第8期2169-2176,共8页
Drugs & Clinic
基金
广东省促进经济高质量发展(海洋经济发展)海洋六大产业专项基金(GDNRC[2022]38)。
关键词
抗癌肽
细胞膜
细胞凋亡
血管生成
免疫调节
DNA损伤
细胞增殖
临床应用
anticancer peptides
cell membrane
apoptosis
angiogenesis
immune regulation
DNA damage
cell proliferation
clinical application
