摘要
目的:观察重组人干扰素α2a联合微波治疗慢性宫颈炎合并人乳头瘤病毒(HPV)感染患者的效果。方法:回顾性分析2022年11月至2023年11月该院收治的126例慢性宫颈炎合并HPV感染患者的临床资料,按照治疗方法不同将其分为对照组和观察组各63例。对照组采用微波治疗,观察组在对照组基础上联合重组人干扰素α2a栓治疗,两组均连续治疗3个月。比较两组临床疗效,症状相关指标(创面愈合时间、排尿正常时间、阴道分泌物正常时间)水平,治疗前后阴道微生态指标(阴道pH值、乳酸杆菌异常率)、炎性因子[白细胞介素-4(IL-4)、白细胞介素-12(IL-12)、γ干扰素(IFN-γ)]水平,HPV转阴率,以及不良反应发生率。结果:观察组治疗总有效率为95.24%(60/63),高于对照组的77.78%(49/63),差异有统计学意义(P<0.05);观察组创面愈合时间、排尿正常时间、阴道分泌物正常时间均短于对照组,差异有统计学意义(P<0.05);治疗后,观察组阴道pH值、乳酸杆菌异常率均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组IL-4水平低于对照组,IL-12、IFN-γ水平高于对照组,差异均有统计学意义(P<0.05);观察组HPV转阴率为65.08%(41/63),高于对照组的34.92%(22/63),差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:重组人干扰素α2a联合微波治疗慢性宫颈炎合并HPV感染患者可提高治疗总有效率和HPV转阴率,改善症状相关指标、炎性因子水平,降低阴道微生态指标水平,效果优于单纯微波治疗。
Objective:To observe effects of recombinant human interferonα2a combined with microwave in treatment of patients with chronic cervicitis complicated with human papillomavirus(HPV)infection.Methods:The clinical data of 126 patients with chronic cervicitis complicated with HPV infection admitted to the hospital from November 2022 to November 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,63 cases in each group.The control group was treated with microwave,while the observation group was treated with recombinant human interferonα2a suppository on the basis of that of the control group.Both groups were treated continuously for 3 months.The clinical efficacy,the levels of symptom-related indicators(wound healing time,normal urination time,normal vaginal secretion time),vaginal microecological indicators(vaginal pH value,abnormal rate of Lactobacilli),and inflammatory factors[interleukin-4(IL-4),interleukin-12(IL-12),interferon-γ(IFN-γ)]levels before and after the treatment,the HPV negative conversion rate,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 95.24%(60/63),which was higher than 77.78%(49/63)of the control group,and the difference was statistically significant(P<0.05).The wound healing time,the normal urination time,and the normal vaginal secretion time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the vaginal pH value and the abnormal rate of Lactobacilli in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the level of IL-4 in the observation group was lower than that in the control group,the levels of IL-12 and IFN-γwere higher than those in the control group,and the differences were statistically significant(P<0.05).The HPV negative conversion rate in the observation group was 65.08%(41/63),which was higher than 34.92%(22/63)in the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Recombinant human interferonα2a combined with microwave in the treatment of the patients with chronic cervicitis and HPV infection can improve the total effective rate of treatment and the HPV negative conversion rate,improve the levels of symptom-related indicators and inflammatory factors,and reduce the levels of vaginal microecological indicators.Moreover,it is superior to simple microwave therapy treatment.
作者
李静
LI Jing(Department of Obstetrics and Gynecology of Jinshui District General Hospital,Zhengzhou 450015 Henan,China)
出处
《中国民康医学》
2024年第19期71-73,77,共4页
Medical Journal of Chinese People’s Health
关键词
慢性宫颈炎
人乳头瘤病毒感染
重组人干扰素Α2A
微波
阴道微生态
炎性因子
不良反应
Chronic cervicitis
Human papillomavirus infection
Recombinant human interferonα2a
Microwave
Vaginal microecology
Inflammatory factor
Adverse reaction
