摘要
目的:观察柴胡桂枝汤、当归芍药散、桂枝茯苓丸合方加减治疗痰瘀阻络型糖尿病周围神经病变(DPN)的临床疗效。方法:将60例痰瘀阻络型DPN患者纳入研究,根据随机数字表法分为治疗组和对照组各30例。对照组采用西医常规治疗,治疗组在对照组基础上加柴胡桂枝汤、当归芍药散、桂枝茯苓丸合方加减治疗。2组疗程均为30 d。观察2组临床疗效,以及治疗前后中医证候评分、正中神经和腓总神经的运动神经传导速度(MNCV)、感觉神经传导速度(SNCV)、震动感觉阈值变化。结果:治疗后,治疗组总有效率为93.33%,对照组为73.00%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组中医证候评分均低于治疗前,且治疗组低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组感觉阈值均低于治疗前,且治疗组低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组正中神经和腓总神经的MNCV、SNCV高于治疗前,且治疗组高于对照组,差异均有统计学意义(P<0.05)。治疗过程中,2组均未见明显不良反应发生。结论:柴胡桂枝汤、当归芍药散、桂枝茯苓丸合方加减治疗痰瘀阻络型DPN可提高临床疗效,减轻感觉异常,改善神经传导速度及中医证候。
Objective:To observe the clinical effect of modified Chaihu Guizhi Decoction,Danggui Shaoyao Powder and Guizhi Fuling Pills on diabetic peripheral neuropathy(DPN)of phlegm-stasis blocking collaterals type.Methods:A total of 60 cases of patients with DPN of phlegm-stasis blocking collaterals type were included in this study and divided into the treatment group and the control group according to random number table method,with 30 patients in each group.The control group was treated with conventional western medicine,and the treatment group was supplemented with modified Chaihu Guizhi Decoction,Danggui Shaoyao Powder and Guizhi Fuling Pills.Both groups underwent one treatment course lasting 30 days.The changes in traditional Chinese medicine(TCM)syndrome scores,motor nerve conduction velocity(MNCV)of median nerve and common peroneal nerve,sensory nerve conduction velocity(SNCV)and vibration perception thresholds before and after treatment as well as the clinical effects in the two groups were observed.Results:After treatment,the total effective rate was 93.33%in the treatment group and 73.00%in the control group,and the difference between the two groups was significant(P<0.05).After treatment,the TCM syndrome scores in the two groups were lower than those before treatment,and the score in the treatment group was lower than that in the control group,differences being significant(P<0.05).After treatment,the perception thresholds in the two groups were decreased when compared with those before treatment,and the perception threshold in the treatment group was lower than that in the control group,differences being significant(P<0.05).After treatment,MNCV and SNCV of median nerve and common peroneal nerve in the two groups were higher than those before treatment,and the above indexes in the treatment group were higher than those in the control group,differences being significant(P<0.05).In the course of treatment,no obvious adverse reaction was observed in both groups.Conclusion:The combination of Chaihu Guizhi Decoction,Danggui Shaoyao Powder and Guizhi Fuling Pills treatment DPN of phlegm-stasis blocking collateral type can increase the clinical effect,alleviate paresthesia,and improve nerve conduction velocity and TCM syndrome.
作者
苏畅怡
黄文锋
林红坤
SU Changyi;HUANG Wenfeng;LIN Hongkun(Guangzhou University of Chinese Medicine,Guangzhou Guangdong 510006,China;Zhanjiang First Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine,Zhanjiang Guangdong 524000,China)
出处
《新中医》
CAS
2024年第18期13-17,共5页
New Chinese Medicine
基金
广东省中医药局中医药科研项目(20222281)。
关键词
糖尿病周围神经病变
痰瘀阻络型
柴胡桂枝汤
当归芍药散
桂枝茯苓丸
神经传导速度
Diabetic peripheral neuropathy
Phlegm-stasis obstructing collaterals type
Chaihu Guizhi Decoction
Danggui Shaoyao Powder
Guizhi Fuling pills
Nerve conduction velocity
