摘要
目的:观察疏肝理气解郁方联合西药治疗卒中后抑郁的临床疗效及对T淋巴细胞亚群的影响。方法:选择2023年1—12月收治的卒中后抑郁患者104例,按随机数字表法分为治疗组、对照组各52例。对照组给予常规西药治疗,治疗组在对照组基础上加用疏肝理气解郁方治疗,2组均治疗8周。比较2组治疗前后中医证候积分、抑郁症状评分[汉密尔顿抑郁量表(HAMD)评分、抑郁自评量表(SDS)评分]及T淋巴细胞亚群水平,并评估2组临床疗效及不良反应发生情况。结果:治疗组总有效率92.31%,高于对照组76.92%(P<0.05)。治疗后,2组中医证候积分、SDS评分、HAMD评分及CD8^(+)水平均较治疗前降低(P<0.05),CD3^(+)、CD4^(+)水平升高(P<0.05);治疗组中医证候积分、SDS评分、HAMD评分及CD8^(+)水平低于对照组(P<0.05),CD3^(+)、CD4^(+)水平高于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:疏肝理气解郁方联合西药治疗卒中后抑郁效果良好,能够减轻患者抑郁症状,调节T淋巴细胞亚群水平,安全性较高。
Objective:To observe the clinical effect of Shugan Liqi Jieyu Prescription combined with western medicine on post-stroke depression and its effect on T lymphocyte subsets.Methods:A total of 104 patients with post-stroke depression admitted from January 2023 to December 2023 were randomly divided into the treatment group and the control group,with 52 cases in each group,using a random number table method.The control group received conventional western medicine treatment,and the treatment group received additional treatment with the Shugan Liqi Jieyu Prescription on the basis of the control group.Both groups were treated for eight weeks.Compared the traditional Chinese medicine(TCM)syndrome scores,depression symptom scores[Hamilton Depression Scale(HAMD)scores,and Self-Rating Depression Scale(SDS)scores],and T lymphocyte subsets levels between the two groups before and after treatment,and evaluated the clinical efficacy and incidence of adverse reactions in both groups.Results:The total effective rate of the treatment group was 92.31%,which was higher than that of 76.92%in the control group(P<0.05).After treatment,the TCM syndrome scores,SDS scores,HAMD scores,and CD8^(+)levels in both groups were decreased when compared with those before treatment(P<0.05),while the levels of CD3^(+)and CD4^(+)were increased(P<0.05);The TCM syndrome score,SDS score,HAMD score,and CD8^(+)level in the treatment group were lower than those in the control group(P<0.05),and the levels of CD3^(+)and CD4^(+)were higher than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Shugan Liqi Jieyu Prescription combined with western medicine has a good therapeutic effect on post-stroke depression,which can alleviate the symptoms of depression in patients,regulate the levels of T lymphocyte subsets,and is relatively safe.
作者
徐晏雯
徐勇明
温晗
陈芬芬
王传刘
林海燕
杨铭
张麟
XU Yanwen;XU Yongming;WEN Han;CHEN Fenfen;WANG Chuanliu;LIN Haiyan;YANG Ming;ZHANG Lin(Department of Neurological,Quzhou People's Hospital,Quzhou Zhejiang 324000,China)
出处
《新中医》
CAS
2024年第18期50-54,共5页
New Chinese Medicine
基金
衢州市指导性科技攻关项目(2022021)。
关键词
卒中后抑郁
疏肝理气解郁方
汉密尔顿抑郁量表评分
抑郁自评量表评分
T淋巴细胞亚群
Post-stroke depression
Shugan Liqi Jieyu Prescription
Hamilton Depression Scale scores
Self-Rating Depression Scale scores
T lymphocyte subsets
