摘要
超声神经调控可无创、精准调控脑深部神经核团,为神经科学基础研究和脑疾病治疗干预提供了全新手段,得到了广泛的关注,是神经调控领域的前沿热点研究方向。本文综述了超声神经调控研究进展,重点阐述了体波换能器、声表面波器件和光声器件三类超声神经调控声学器件的原理与发展,分析了超声神经调控的机理研究,以及探讨了超声神经调控的生物医学应用。本文最后对超声神经调控研究进行了总结和展望,并探讨了声遗传学的未来发展。
Ultrasound neuromodulation offers a non-invasive method for precisely regulating deep brain nuclei,providing a novel method for fundamental neuroscience research and brain disorders treatment.Ultrasound neuromodulation has received widespread attention,becoming a cutting-edge of neuromodulation.This article reviews the research progress in ultrasound neuromodulation,with a focus on the principles and the development of three types of ultrasound neuromodulation devices,including bulk acoustic wave transducers,surface acoustic wave devices,and optoacoustic devices.Additionally,the mechanisms research of advancements in ultrasound neuromodulation are analyzed.Furthermore,biomedical applications of ultrasound neuromodulation are discussed.Finally,this article provides an outlook on ultrasound neuromodulation,and explores the future development of sonogenetics.
作者
余卓熙
周伟
刘秀芳
牛丽丽
孟龙
Yu Zhuoxi;Zhou Wei;Liu Xiufang;Niu Lili;Meng Long(Paul C.Lauterbur Research Center for Biomedical Imaging,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China;University of Chinese Academy of Sciences,Beijing 100049,China)
出处
《仪器仪表学报》
EI
CAS
CSCD
北大核心
2024年第6期29-41,共13页
Chinese Journal of Scientific Instrument
关键词
超声神经调控
超声脑刺激
超声辐射力
机械敏感离子通道
声遗传学
ultrasound neuromodulation
ultrasound stimulation
acoustic radiation force
mechanical sensitive ion channel
sonogenetics
