摘要
目的 探讨感染性噬血细胞综合征的临床特点及基层医院可行的治疗方法。方法 选取2021年1月至2023年5月我院收治的11例小儿感染性噬血细胞综合征患儿,采用地塞米松+免疫球蛋白治疗的感染性噬血细胞综合征病例诊治资料进行回顾性分析,与传统化疗为主的综合治疗对比,分析患儿治疗成功率、预后,综合评价临床疗效。结果 11例患儿均继发于感染性疾病,诊断后积极针对原发病因抗感染及地塞米松+免疫球蛋白冲击治疗,7例治愈,3例死亡,1例失访。结论 儿童感染性噬血细胞综合征为临床少见的急危重症,病死率高,积极针对原发病抗感染及联合地塞米松+免疫球蛋白冲击治疗为较有效的治疗方法,值得基层医疗机构推广。
Objective To investigate the clinical characteristics of infectious hemophagocytic syndrome(IHS)and the feasible treatment in primary hospitals.Methods Eleven children with infantile hemophagocytic syndrome admitted to our hospital from January 2021 to May 2023 were selected for retrospective analysis of the diagnosis and treatment data of infantile hemophagocytic syndrome treated with dexamethasone+immunoglobulin.The results were compared with traditional chemotherapy based comprehensive treatment,analyzing the success rate and prognosis of the patients,and comprehensively evaluating the clinical efficacy.Results All 11 patients were secondary to infectious diseases.After diagnosis,they actively targeted the primary cause of infection and dexamethasone+immunoglobulin pulse therapy.Seven patients were cured,three died,and one lost follow-up.Conclusions Infectious hemophagocytic syndrome in children is a rare and critical illness with a high mortality rate.Actively targeting the primary disease for anti infection and combining dexamethasone+immunoglobulin shock therapy are more effective treatment methods,which are worth promoting in grassroots medical institutions.
作者
吉学元
陆睿
卢金暖
权红
邹璐檐
张倡溶
解清清
罗世清
李兴迪
何德丽
JI Xueyuan;LU Rui;LU Jinnuan;QUAN Hong;ZOU Luyan;ZHANG Changrong;XIE Qingqing;LUO Shiqing;LI Xingdi;HE Deli(Department of Pediatrics,the People's Hospital of Wenshan Prefecture,Wenshan 663099,China)
出处
《中国医药指南》
2024年第27期5-7,共3页
Guide of China Medicine
基金
文山州人民医院科研项目(YBXM2021020)。
关键词
感染性噬血细胞综合征
地塞米松
免疫球蛋白
诊断
治疗
Infectious hemophagocytic syndrome
Dexamethasone
Immunoglobulin
Diagnosis
Treatment
