摘要
目的探讨葛根芩连汤加减联合二甲双胍对2型糖尿病(type 2 diabetes mellitus,T2DM)胃肠湿热证患者的影响。方法选取2022年4月—2023年12月深圳市中医院收治的78例T2DM胃肠湿热证患者为研究对象,根据不同治疗方法分为对照组和观察组,各39例。对照组口服盐酸二甲双胍片,观察组在对照组基础上给予葛根芩连汤加减治疗。对比两组的中医证候积分、血糖水平(空腹血糖、餐后2 h血糖、糖化血红蛋白)、胰岛功能(胰岛素抵抗指数、胰岛β细胞功能指数)、不良反应。结果治疗后,观察组的中医证候积分低于对照组,差异有统计学意义(P<0.05)。观察组空腹血糖、餐后2 h血糖、糖化血红蛋白水平均低于对照组,差异有统计学意义(P均<0.05)。治疗后,两组胰岛素抵抗指数水平均降低,且观察组低于对照组,两组胰岛β细胞功能指数均提高,且观察组高于对照组,差异有统计学意义(P均<0.05)。结论在T2DM胃肠湿热证患者中使用葛根芩连汤加减与二甲双胍联合治疗,可有效改善中医证候、血糖水平及胰岛功能,安全性高。
Objective To investigate the effect of modified Gegen Qinlian Decoction combined with metformin on pa⁃tients with type 2 diabetes mellitus(T2DM)with gastrointestinal damp-heat syndrome.Methods A total of 78 patients with T2DM gastrointestinal damp-heat syndrome admitted to Shenzhen Traditional Chinese Medicine Hospital from April 2022 to December 2023 were selected as the research objects.According to different treatment methods,they were divided into control group and observation group,with 39 cases in each group.The control group was given met⁃formin hydrochloride tablets orally.The observation group was given modified Gegen Qinlian Decoction on the basis of the control group.The traditional chinese medicine syndrome scores,blood glucose levels(fasting plasma glucose,2-hour postprandial plasma glucose,glycated hemoglobin A1c),islet function(insulin resistance index,isletβcell func⁃tion index)and adverse reactions were compared between the two groups.Results After treatment,the traditional chi⁃nese medicine syndrome score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).The levels of fasting plasma glucose,2-hour postprandial plasma glucose and glycated hemoglobin A1c in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the levels of insulin resistance index in the two groups decreased,and that in the observation group was lower than that in the control group,the isletβcell function index in the two groups increased,and that in the observation group was higher than that in the control group,and the differences were statistically significant(all P<0.05).Conclusion The combination of Gegen Qinlian Decoction and metformin in pa⁃tients with T2DM gastrointestinal damp-heat syndrome can effectively improve traditional chinese medicine symp⁃toms,blood glucose levels and islet function,with high safety.
作者
肖小惠
李惠林
刘德亮
黄小妮
赵恒侠
王喜明
张鹏翔
XIAO Xiaohui;LI Huilin;LIU Deliang;HUANG Xiaoni;ZHAO Hengxia;WANG Ximing;ZHANG Pengxiang(Department of Endocrinology,Shenzhen Traditional Chinese Medicine Hospital,Shenzhen 518000,Guangdong,China;Fourth Clinical Medical College,Guangzhou University of Traditional Chinese Medicine,Shenzhen 518000,Guangdong,China)
出处
《糖尿病新世界》
2024年第13期1-3,19,共4页
Diabetes New World
基金
广东省基础与应用基础研究基金委员会(2021A1515220177)。
关键词
2型糖尿病
胃肠湿热证
葛根芩连汤加减
二甲双胍
中医证候积分
胰岛功能
Type 2 diabetes mellitus
Gastrointestinal damp-heat syndrome
Modified Gegen Qinlian Decoction
Metformin
Traditional chinese medicine syndrome integral
Islet function
