摘要
目的探讨术前预后营养指数(PNI)-D-二聚体(D-D)评分(PDS)在结直肠癌预后评估中的应用价值。方法纳入2019年1月至2022年12月西华县人民医院收治的结直肠癌根治术后患者进行回顾性研究。根据PNI和D-D水平,将患者分为PDS0组(PNI降低和D-D升高)、PDS1(PNI降低和D-D降低或PNI升高和D-D升高)和PDS2组(PNI升高和D-D降低)。用Kaplan-Meier法和Log-rank检验比较各组疾病无进展生存期和总生存期,并确定预后的危险因素。结果本研究共纳入67例结直肠癌患者,包括PDS021例、PDS124例和PDS222例。PNI、D-D和PDS均对结直肠癌患者疾病无进展生存期和总生存期有一定的预测价值,其曲线下面积分别为0.776(0.715~0.838)、0.729(0.669~0.790)、0.795(0.736~0.853)和0.789(0.723~0.855)、0.739(0.676~0.803)、0.817(0.757~0.877)。对疾病无进展生存期和总生存期的预测均是PDS具有最大的曲线下面积,效能最佳。PDS亚组间的疾病无进展生存期和总生存期比较差异均有统计学意义(P均<0.001)。多因素COX风险比例回归分析表明,PNI、D-D和PDS均与疾病无进展生存期和总生存期的密切相关(P均<0.001)。结论PDS是结直肠癌根治性术后患者有用的预后指标,PDS0患者的生存较差。
Objective To explore the prognostic value of preoperative prognostic nutritional index(PNI)-D-Dimer(D-D)score(PDS)in the colorectal cancer.Methods A retrospective study was conducted on patients with colorectal cancer who underwent radical surgery and were admitted to Xihua County People’s Hospital from January 2019 to December 2022.According to the levels of PNI and D-D,the patients were divided into the PDS0 group(PNI decreased and D-D increased),the PDS1 group(PNI decreased and D-D decreased or PNI increased and D-D increased),and the PDS2 group(PNI increased and D-D decreased).disease-free survival and overall survival between the two groups were compared by using Kaplan-Meier method and Log-rank test,and the risk factors for prognosis was determined.Results The 67 patients with colorectal cancer were included in this study,including 21 patients with PDS0,24 patients with PDS1,and 22 patients with PDS2.PNI,D-D and PDS all had predictive value for disease progression-free survival and overall survival in patients with colorectal cancer,with areas under the curve of 0.776(0.715-0.838),0.729(0.669-0.790),0.795(0.736-0.853)and 0.789(0.723-0.855),0.739(0.676-0.803),0.817(0.757-0.877),respectively.PDS had the largest area under the curve and the best performance in predicting disease progression-free survival and overall survival.There were significant differences in disease progression-free survival and overall survival between PDS subgroups(P<0.001).Multivariate COX proportional hazards regression analysis showed that PNI,D-D and PDS were closely related to disease progression-free survival and overall survival(P<0.001).Conclusion PDS is a useful prognostic indicator for patients with colorectal cancer after radical surgery,and the survival of patients with PDS0 is poor.
作者
牛亚楠
吕海军
袁文清
NIU Yanan;LYU Haijun;YUAN Wenqing(Department of Laboratory,Xihua County People’s Hospital,Xihua 466699,China;Department of Laboratory,Zhoukou Central Hospital,Zhoukou 466099,China)
出处
《肿瘤基础与临床》
2024年第5期529-532,共4页
journal of basic and clinical oncology
关键词
结直肠癌
预后营养指数
D-二聚体
预后
colorectal cancer
prognostic nutritional index
D-Dimer
prognosis
