摘要
中枢神经系统疾病会严重影响患者的日常生活和工作能力,并给患者家庭带来沉重的经济负担。近年来,随着生活质量的不断提高和老龄化问题的日益加剧,中枢神经系统疾病的发病率呈现出显著上升的趋势。因此,寻找新的防治药物一直是该类疾病的研究热点。从蛇床子、当归、独活等伞形科植物中分离出来的蛇床子素(osthole,OST)具有神经保护、抗氧化、抗炎以及抗血栓形成等多种药理作用。越来越多的证据表明,OST在多种中枢神经系统疾病模型中展现出了显著的防治效果。该文查阅国内外文献资料,系统综述了OST在防治中枢神经系统疾病方面的研究进展,为OST在未来防治中枢神经系统疾病的临床应用提供更深入的理论支撑。
Central nervous system(CNS)disorders can significantly impact patients′daily lives,impairing their ability to work and imposing a substantial financial burden on their families.In recent years,the incidence of CNS diseases has shown a significant increase with the continuous improvement of the quality of life and the aging problem.Therefore,the search for new preventive and curative drugs has been a research hotspot for this group of diseases.Osthole(OST),isolated from Umbelliferae such as Cnidium monnieri,Angelica sinensis,and Heracleum hemsleyanum,possesses a variety of pharmacological effects such as neuroprotective,antioxidant,anti-inflammatory,and antithrombotic effects.There is increasing evidence that OST has demonstrated significant preventive and curative effects in various CNS disease models.This paper systematically reviewed the research progress of OST in preventing and treating CNS diseases by reviewing domestic and international literature to provide more in-depth theoretical support for the future clinical application of OST in the prevention and treatment of CNS diseases.
作者
张千
钟光成
李舒婷
王雪婧
郑珏彦
张泽荣
罗柏榤
李伟荣
王奇
ZHANG Qian;ZHONG Guang-cheng;LI Shu-ting;WANG Xue-jing;ZHENG Jue-yan;ZHANG Ze-rong;LUO Bo-jie;LI Wei-rong;WANG Qi(Science and Technology Innovation Center,Guangzhou University of Chinese Medicine,Guangzhou 510405,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2024年第17期4650-4657,共8页
China Journal of Chinese Materia Medica
基金
国家自然科学基金面上项目(82274616)
广东省科技计划国际合作项目(2020A0505100052)
广东省基础与应用基础研究基金企业联合基金项目(2022A1515220121)。
关键词
蛇床子素
中枢神经系统疾病
神经保护
阿尔茨海默病
脑缺血
osthole
central nervous system diseases
neuroprotection
Alzheimer′s disease
cerebral ischemia
