摘要
目的:探究原发性喉癌血清环氧合酶-2(COX-2)、垂体瘤转化基因1(PTTG1)、Toll样受体4(TLR4)水平与临床病理特征及预后生存状况的关系。方法:选取2021年5月至2023年3月四川省达州市中心医院105例原发性喉癌患者、105例喉部良性病变患者分别作为观察组和对照组。比较两组血清COX-2、PTTG1、TLR4水平,多元线性回归分析血清COX-2、PTTG1、TLR4水平与临床病理特征的关系,随访3年,比较不同血清COX-2、PTTG1、TLR4水平患者预后生存率。结果:观察组COX-2、PTTG1、TLR4水平分别为(38.89±12.14)ng/L、(140.17±30.25)pg/mL、(13.94±3.25)ng/mL均高于对照组(17.63±5.09)ng/L、(98.49±15.63)pg/mL、(8.72±2.13)ng/mL(t=16.549、12.543、13.765,P均<0.05);多元线性回归分析显示,临床分期(偏回归系数:0.714、0.722、0.719)、肿瘤分化程度(偏回归系数:0.756、0.749、0.798)及淋巴结转移(偏回归系数:0.802、0.798、0.713)均为原发性喉癌患者血清COX-2、PTTG1、TLR4水平的影响因素(P<0.05);COX-2高水平亚组3年总生存率、总生存率分别为80.77%、71.15%,明显高于低水平亚组95.83%、87.50%(P<0.05);PTTG1高水平亚组3年总生存率、总生存率分别为80.39%、68.63%,明显高于低水平亚组95.92%、89.80%(P<0.05);TLR4高水平亚组3年总生存率、总生存率分别为78.85%、71.15%,明显高于低水平亚组97.92%、87.50%(P<0.05)。结论:原发性喉癌患者血清COX-2、PTTG1、TLR4水平均较高,且其高水平状态与临床分期、肿瘤分化程度及淋巴结转移有关,检测COX-2、PTTG1、TLR4水平可在一定程度上反映患者预后生存情况。
Objective:To investigate the relationship between serum cyclooxygenase-2(COX-2),pituitary tumor transforming gene 1(PTTG1),toll-like receptor 4(TLR4)levels and clinicopathological features,prognosis,and survival of primary laryngeal cancer.Methods:A total of 105 patients with primary laryngeal cancer and 105 patients with benign laryngeal lesions in Dazhou City Central Hospital of Sichuan Province from May 2021 to March 2023 were selected as observation and control groups,respectively.The serum COX-2,PTTG1 and TLR4 levels of the two groups were compared,and the relationship between serum COX-2,PTTG1 and TLR4 levels,and clinicopathological features was analyzed using multiple linear regression,and the prognostic survival rate of the patients with different serum COX-2,PTTG1,and TLR4 levels was compared in the follow-up of 3 years.Results:The levels of COX-2,PTTG1,and TLR4 in the observation group were(38.89±12.14)ng/L,(140.17±30.25)pg/mL,and(13.94±3.25)ng/mL,respectively,which were higher than those in the control group(17.63±5.09)ng/L,(98.49±15.63)pg/mL,and(8.72±2.13)ng/mL(t=16.549,12.543,13.765,all P<0.05).Multiple linear regression analysis showed that clinical stage(partial regression coefficient:0.714,0.722,0.719),tumor differentiation degree(partial regression coefficient:0.756,0.749,0.798),and lymph node metastasis(partial regression coefficient:0.802,0.798,0.713)were the influencing factors for the levels of serum COX-2,PTTG1,and TLR4 in patients with primary laryngeal cancer(P<0.05).The 3-year overall survival rate and overall survival rate of the COX-2 high-level subgroup were 80.77%and 71.15%,respectively,which were significantly higher than those of the low-level subgroup 95.83%and 87.50%(P<0.05);the 3-year overall survival rate and overall survival rate of the PTTG1 high-level subgroup were 80.39%and 68.63%,respectively,which were significantly higher than those of the low-level subgroup 95.92%and 89.80%(P<0.05);3-year overall survival rate and overall survival rate of TLR4 high-level subgroup were 78.85%and 71.15%,respectively,which were significantly higher than those of 97.92%and 87.50%in the low-level subgroup(P<0.05).Conclusion:The levels of serum COX-2,PTTG1,and TLR4 are high in patients with primary laryngeal cancer,and their high levels are related to clinical stage,tumor differentiation,and lymph node metastasis.Detection of COX-2,PTTG1,and TLR4 levels can reflect the prognosis and survival of patients to a certain extent.
作者
吴建
杨令
王东
WU Jian;YANG Ling;WANG Dong(Dazhou Central Hospital,Sichuan Dazhou 635000,China)
出处
《河北医学》
CAS
2024年第9期1525-1530,共6页
Hebei Medicine
基金
2021年四川省医学(青年创新)科研课题项目,(编号:S21525)。
