摘要
目的:探究双歧杆菌四联活菌片联合小麦纤维素颗粒治疗儿童功能性便秘的效果。方法:选取2022年6月—2023年6月于德阳市人民医院治疗的102例功能性便秘患儿作为研究对象,采用随机数表法将其分为对照组和研究组,各51例。对照组采用乳果糖口服溶液治疗,研究组在对照组基础上给予双歧杆菌四联活菌片联合小麦纤维素颗粒治疗,比较两组治疗效果、肠黏膜屏障功能[二胺氧化酶(DAO)、降钙素原(PCT)]、肠神经递质[血管活性肠肽(VIP)、P物质(SP)]、肠道菌群及便秘症状评分。结果:治疗后,与对照组比较,研究组临床总有效率更高,差异有统计学意义(P<0.05)。治疗前,两组黏膜屏障功能、肠神经递质、肠道菌群及便秘症状评分比较,差异无统计学意义(P>0.05);治疗后,两组DAO、PCT、VIP水平、排便频次评分、排便困难评分降低,且研究组更低,两组SP、双歧杆菌、乳酸菌水平升高,且研究组更高,差异有统计学意义(P<0.05)。结论:双歧杆菌四联活菌片联合小麦纤维素颗粒可以调节儿童功能性便秘患儿的肠道菌群和肠神经递质水平,保护肠黏膜屏障,促进症状改善,提高临床疗效。
Objective:To explore the effect of Bifidobacterium Tetrad Viable Tablets combined with Wheat Cellulose Granules in the treatment of functional constipation in children.Method:A total of 102 children with functional constipation who treated in Deyang People's Hospital from June 2022 to June 2023 were selected,they were divided into the control group and the study group by random number table method,with 51 cases in each group.The control group was treated with Lactulose Oral Solution,while the study group was treated with Bifidobacterium Tetrad Viable Tablets combined with Wheat Cellulose Granules on the basis of the control group.The therapeutic effect,intestinal mucosal barrier function[diamine oxidase(DAO),procalcitonin(PCT)],intestinal neurotransmitters[vasoactive intestinal peptide(VIP),substance P(SP)],intestinal flora and constipation symptom scores were compared between two groups.Result:After treatment,compared with the control group,the total clinical effective rate of the study group was higher,and the difference was statistically significant(P<0.05).Before treatment,there were no significant difference in the intestinal mucosal barrier function,intestinal neurotransmitters,intestinal flora and constipation symptom scores between two groups(P>0.05);after treatment,the DAO,PCT,VIP levels,defecation frequency score and defecation difficulty score in two groups were decreased,and those in the study group were lower,the SP,Bifidobacteria and lactic acid bacteria levels in two groups were increased,and those in the study group were higher,the differences were statistically significant(P<0.05).Conclusion:Bifidobacterium Tetrad Viable Tablets combined with Wheat Cellulose Granules in the treatment of functional constipation in children can regulate the intestinal flora and intestinal neurotransmitters levels,protect the intestinal mucosal barrier function,and then alleviate clinical symptoms and improve clinical efficacy.
作者
刘琳
刘前芳
王风洋
LIU Lin;LIU Qianfang;WANG Fengyang(Deyang People's Hospital,Deyang 618000,China;不详)
出处
《中外医学研究》
2024年第26期30-34,共5页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
双歧杆菌四联活菌片
小麦纤维素颗粒
功能性便秘
肠道菌群
肠黏膜屏障
肠神经递质
Bifidobacterium Tetrad Viable Tablets
Wheat Cellulose Granules
Functional constipation
Intestinal flora
Intestinal mucosal barrier
Intestinal neurotransmitters
