摘要
目的:探讨桉柠蒎肠溶软胶囊联合布地奈德鼻喷雾剂对慢性鼻窦炎患者的影响。方法:选取2020年1月—2022年12月三明市第一医院收治的94例慢性鼻窦炎患者作为研究对象,采用随机数表法分成研究组(n=47)和对照组(n=47),其中对照组失访5例,研究失访2例,最终研究组45例,对照组42例。两组均给予鼻内镜手术,对照组术后给予布地奈德鼻喷雾剂干预,研究组于对照组基础上给予桉柠蒎肠溶软胶囊干预。比较两组疗效,炎症因子,鼻黏液纤毛传输速度以及功能评分[鼻黏膜结构(Lund-Mackay)评分、鼻腔鼻窦结局测试-20(SNOT-20)评分]。结果:治疗后,研究组炎症因子水平、Lund-Mackay评分、SNOT-20评分更低,鼻黏液纤毛传输速度更快,差异有统计学意义(P<0.05);疗程结束后1年,研究组临床总有效率更高,差异有统计学意义(P<0.05)。结论:桉柠蒎肠溶软胶囊联合布地奈德鼻喷雾剂可以有效的缓解慢性鼻窦炎的炎症水平,改善患者的临床症状,提高鼻黏液纤毛传输速度,提高治疗效果。
Objective:To investigate the effect of eucalyptol,limonene and pinene enteric soft capsule combined with budesonide nasal spray on patients with chronic sinusitis.Method:A total of 94 patients with chronic sinusitis admitted to the First Hospital of Sanming City from January 2020 to December 2022 were selected as the study objects.They were divided into study group(n=47)and control group(n=47)by random number table method.5 cases in the control group were lost to follow-up,2 cases were lost to study follow-up,and 45 cases in the final study group and 42 cases in the control group.Patients in both groups were given nasal endoscopic surgery,the control group was given budesonide nasal spray intervention after surgery,and the study group was given eucalyptus,limonene pinene enteric soft capsules on the basis of the control group.Nasal mucociliary transport velocity and function score[Nasal mucosal structure(Lund-Mackay)score,Sinusoidal Outcomes Test-20(SNOT-20)score]were compared between the two groups.Result:After treatment,the levels of inflammatory factors,Lund-Mackay score,SNOT-20 score of the study group were lower,the nasal mucociliary transmission speed was faster,1 year after the end of the treatment,the total clinical effective rate of the study group was higher,and the difference was statistically significant(P<0.05).Conclusion:Eucalyptol,limonene and pinene enteric soft capsule combined with budesonide nasal spray can effectively relieve the inflammation level of chronic sinusitis,improve the clinical symptoms of patients,improve the nasal mucociliary transmission speed,and improve the therapeutic effect.
作者
詹光晔
李灵锴
ZHAN Guangye;LI Lingkai(The First Hospital of Sanming,Sanming 365001,China;不详)
出处
《中外医学研究》
2024年第27期61-64,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
慢性鼻窦炎
桉柠蒎肠溶软胶囊
布地奈德鼻喷雾剂
炎症因子
疗效
Chronic sinusitis
Eucalyptol,limonene and pinene enteric soft capsules
Budesonide nasal spray
Inflammatory factors
Efficacy
