摘要
目的 探讨胰腺肿瘤伴血糖异常患者检验肿瘤标志物指标的影响。方法 选取80例胰腺肿瘤患者,其中良性胰腺肿瘤患者40例(血糖正常患者20例,血糖异常患者20例),恶性胰腺肿瘤患者40例(血糖正常患者20例,血糖异常患者20例)。两组患者均开展肿瘤标志物检查。比较良性胰腺肿瘤患者与恶性胰腺癌患者以及良性肿瘤、恶性肿瘤患者中血糖正常和血糖异常患者的糖类抗原199(CA199)、癌胚抗原(CEA)、甲胎蛋白(AFP)、糖类抗原125(CA125)、糖类抗原153(CA153)水平。结果 恶性胰腺肿瘤患者CA199(76.37±10.16)U/ml、CEA(26.13±6.38)ng/ml、AFP(22.32±7.19)ng/ml、CA125(63.85±12.11)U/ml、CA153(45.96±10.27)U/ml均明显高于良性胰腺肿瘤患者的(13.20±2.11)U/ml、(2.65±0.35)ng/ml、(3.37±0.13)ng/ml、(13.79±2.02)U/ml、(7.92±1.21)U/ml(P<0.05)。恶性胰腺肿瘤血糖异常患者的CA199(86.41±10.19)U/ml、CEA(30.63±6.26)ng/ml、AFP(28.13±8.27)ng/ml、CA125(68.77±3.10)U/ml、CA153(50.16±4.24)U/ml均高于血糖正常患者的(66.33±10.14)U/ml、(21.63±7.22)ng/ml、(16.51±7.24)ng/ml、(58.93±3.02)U/ml、(41.76±4.21)U/ml(P<0.05)。良性胰腺肿瘤血糖正常和血糖异常患者的CA199、CEA、AFP、CA125、CA153水平比较,无统计学差异(P>0.05)。结论 对于胰腺肿瘤患者来讲,血糖异常对肿瘤标志物指标有明显影响,应予以重点关注,合理控制血糖,从而为疾病的进一步治疗奠定良好条件。
Objective To explore the impact of pancreatic tumors with abnormal blood glucose on tumor markers.Methods 80 patients cases of pancreatic tumor were selected,including 40 patients with benign pancreatic tumors(20 patients with normal blood glucose and 20 patients with abnormal blood glucose)and 40 patients with malignant pancreatic tumors(20 patients with normal blood glucose and 20 patients with abnormal blood glucose).Tumor markers were examined in both groups.The levels of carbohydrate antigen 199(CA199),carcinoembryonic antigen(CEA),alpha-fetoprotein(AFP),glycochain antigen 125(CA125)and carbohydrate antigen 153(CA153)in patients with benign pancreatic cancer and malignant pancreatic cancer were compared,as well as in benign pancreatic tumor patients with normal and abnormal blood glucose,and malignant pancreatic tumor patients with normal and abnormal blood glucose.Results In patients with malignant pancreatic tumors,CA199 was(76.37±10.16)U/ml,CEA was(26.13±6.38)ng/ml,AFP was(22.32±7.19)ng/ml,CA125 was(63.85±12.11)U/ml,and CA153 was(45.96±10.27)U/ml,which were significantly higher than(13.20±2.11)U/ml,(2.65±0.35)ng/ml,(3.37±0.13)ng/ml,(13.79±2.02)U/ml,and(7.92±1.21)U/ml in patients with benign pancreatic tumors(P<0.05).In malignant pancreatic tumor patients with abnormal blood glucose,CA199 was(86.41±10.19)U/ml,CEA was(30.63±6.26)ng/ml,AFP was(28.13±8.27)ng/ml,CA125 was(68.77±3.10)U/ml,and CA153 was(50.16±4.24)U/ml,which were higher than(66.33±10.14)U/ml,(21.63±7.22)ng/ml,(16.51±7.24)ng/ml,(58.93±3.02)U/ml,and(41.76±4.21)U/ml of those with normal blood glucose(P<0.05).Conclusion For patients with pancreatic cancer,abnormal blood glucose has a significant impact on tumor marker indicators,which should be paid attention to and properly controlled,so as to lay a good condition for further treatment of the disease.
作者
翟婷婷
ZHAI Ting-ting(Laboratory Department,Yancheng Dafeng Hospital of Traditional Chinese Medicine,Yancheng 224100,China)
出处
《中国实用医药》
2024年第19期78-81,共4页
China Practical Medicine
关键词
胰腺肿瘤
血糖异常
肿瘤标志物
癌胚抗原
Pancreatic tumors
Abnormal blood glucose
Tumor markers
Carcinoembryonic antigen
