摘要
目的:探究点阵CO_(2)激光联合308 nm准分子光治疗面部白癜风患者面部美学的价值。方法:选取笔者医院2020年3月-2023年2月门诊就诊的108例面部白癜风患者为研究对象,按照单双号法将患者随机分为对照组(54例)和观察组(54例)。对照组使用308 nm准分子光进行治疗,观察组使用点阵CO_(2)激光联合308 nm准分子光治疗。比较两组患者复色开始时间、治疗12周后的复色率及疗效差异;比较两组患者治疗前及治疗12周后皮损区炎症因子水平[白介素-17(InterLeukin-17,IL-17)和白介素-23(InterLeukin-23,IL-23)]、面部美学改善效果[面部整体美学效果改善评分量表(Global aesthetic improvement scale,GAIS)]及生活质量[皮肤病生活质量指数(Dermatology life quality index,DLQI评分)]差异;比较两组患者治疗12周内不良事件发生率(局部皮肤红斑、皮炎、水疱)以及复发率。结果:治疗后,观察组患者复色开始时间明显小于对照组(P<0.05);治疗12周后,观察组复色率、总有效率高于对照组(P<0.05);治疗12周后,两组患者IL-17和IL-23水平较治疗前降低,观察组显著低于对照组(P<0.05);治疗12周后,两组患者GAIS评分较治疗前升高,观察组评分高于对照组(P<0.05),两组患者DLQI评分较治疗前降低,观察组评分低于对照组(P<0.05);围术期内,观察组患者不良反应发生率及复发率显著低于对照组(P<0.05)。结论:点阵CO_(2)激光配合308 nm准分子光治疗面部白癜风临床效果明确,促进皮肤复色进程,减少皮损区炎症反应,改善患者面部美观度和生活质量,安全性及有效性较高,值得临床推广应用。
Objective To explore the value of fractional CO_(2) laser combined with 308 nm excimer laser on facial aesthetics in patients with facial vitiligo.Methods A total of 108 patients with facial vitiligo admitted to the outpatient department of the author's hospital from March 2020 to February 2023 were selected as the study subjects.The patients were randomly divided into a control group(54 cases)and an observation group(54 cases)according to the odd-even number method.The control group was treated with a 308 nm excimer laser,while the observation group received a combination of fractional CO_(2) laser and 308 nm excimer laser.The onset time of color recovery,color recovery rate,and efficacy after 12 weeks of treatment,levels of inflammatory factors in the skin lesion zone[interleukin-17(IL-17),interleukin-23(IL-23)],facial aesthetic improvement effect[Global Aesthetic Improvement Scale(GAIS)],quality of life[Dermatology Life Quality Index(DLQI)]before and after 12 weeks of treatment,and the incidence rates of adverse events(local skin erythema,dermatitis,blisters)and recurrence rate within 12 weeks of treatment were compared between the two groups of patients.Results After treatment,the onset time of color recovery in the observation group was significantly shorter than in the control group(P<0.05).The color recovery rate and total effective rate in the observation group after 12 weeks of treatment were higher than those in the control group(P<0.05).After 12 weeks of treatment,the levels of IL-17 and IL-23 in both groups declined compared to before treatment,with the levels in the observation group being significantly lower than in the control group(P<0.05).The GAIS score in both groups increased after 12 weeks of treatment compared to before treatment,with the score in the observation group being higher than that in the control group(P<0.05).The DLQI score in both groups decreased compared to before treatment,with the score in the observation group being lower than that in the control group(P<0.05).During the perioperative period,the incidence rates of adverse reactions and the recurrence rate in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Fractional CO_(2) laser combined with 308 nm excimer laser demonstrates clear clinical efficacy,promoting skin color recovery,reducing inflammatory response in the skin lesion zone,and improving the facial aesthetics and quality of life of patients,with high safety and effectiveness.
作者
王莉
杨浩
陈梅
凌萍
李伟
刘国刚
WANG Li;YANG Hao;CHEN Mei;LING Ping;LI Wei;LIU Guogang(Department of Dermatology,Ziyang Central Hospital,Ziyang 641300,Sichuan,China)
出处
《中国美容医学》
CAS
2024年第10期57-61,共5页
Chinese Journal of Aesthetic Medicine
