摘要
目的:观察开璇玑联合按弦搓摩复式推拿配合中药治疗小儿厌食症临床疗效及其对患儿血清胃肠激素、血清食欲调节因子水平和营养状况的影响。方法:将84例厌食症患儿按随机数字表法分为观察组和对照组各42例,对照组给予不换金正气散加减治疗,观察组在对照组基础上给予开璇玑联合按弦搓摩复式推拿治疗。观察两组患儿治疗前后中医证候评分、血清胃肠激素(胃动素、胃泌素)、血清食欲调节因子(神经肽Y、促食欲素、瘦素)、营养状况(血锌、血钙、血红蛋白)的变化,并评价两组治疗措施的安全性及疗效。结果:治疗后,两组中医证候评分、血清瘦素水平均较治疗前降低(P<0.05),且观察组低于对照组(P<0.05);两组血清胃动素、胃泌素、神经肽Y、促食欲素水平和血锌、血钙、血红蛋白水平均较治疗前升高(P<0.05),且观察组高于对照组(P<0.05)。两组治疗过程中均未出现严重不良反应。观察组治疗后总有效率高于对照组,两组临床疗效比较,差异有统计学意义(P<0.05)。结论:开璇玑联合按弦搓摩复式推拿配合中药治疗小儿厌食症疗效确切,可降低患儿中医证候评分,改善血清胃肠激素、血清食欲调节因子水平和营养状况。
Objective:To observe the clinical curative efficacy of combination of Kai Xuanji,compound manipulation“An Xian Cuo Mo”and Chinese medicine in treatment of pediatric anorexia and its influence on serum gastrointestinal hormone,serum appetite-regulating factors levels and nutritional status of pediatric patients.Methods:A total of 84 children with anorexia were divided into the observation group and the control group by random number table method,with 42 cases in each group.The control group was treated with modified Buhuanjin Zhengqi Powder(不换金正气散),while the observation group received additional treatment with Kai Xuanji combined with compound massage“An Xian Cuo Mo”on the basis of the control group.The changes in traditional Chinese medicine(TCM)syndrome scores,serum levels of gastrointestinal hormones(motilin and gastrin),serum levels of appetite-regulating factors(neuropeptide Y,orexin,leptin),and nutritional status(blood zinc,calcium,hemoglobin)before and after treatment were observed in the two groups.The safety and curative efficacy of the treatments in the two groups were evaluated.Results:After treatment,the TCM syndrome scores and level of leptin in the two groups were lower than those before treatment(P<0.05),and the TCM syndrome scores and level of serum leptin in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of serum motilin,gastrin,neuropeptide Y,orexin,blood zinc,calcium,and hemoglobin in the two groups all increased compared to before treatment(P<0.05),with the observation group showing higher levels than the control group(P<0.05).There were no severe adverse reations in the two groups during the treatment period.The total effective rate following treatment was higher in the observation group compared to the control group,and there was a statistically significant difference between the two groups(P<0.05).Conclusions:The combination of Kai Xuanji,compound manipulation“An Xian Cuo Mo”and Chinese medicine for pediatric anorexia has definite curative efficacy,as it can reduce the TCM syndrome scores of affected children and improve the levels of serum gastrointestinal hormones,serum appetite-regulating factors,and nutritional status.
作者
冯硕
池莲
周义山
崔德成
FENG Shuo;CHI Lian;ZHOU Yishan;CUI Decheng(Pediatric Department,Shunyi Hospital,Beijing Hospital of Traditional Chinese Medicine,Beijing 101300,China;Cardiology Department,Shunyi Hospital,Beijing Hospital of Traditional Chinese Medicine,Beijing 101300,China)
出处
《山东中医杂志》
2024年第10期1112-1117,共6页
Shandong Journal of Traditional Chinese Medicine
基金
北京中医医院顺义医院院级课题(编号:SYYJLC-202002)。
关键词
开璇玑
按弦搓摩复式推拿
不换金正气散
小儿厌食症
胃肠激素
食欲调节因子
营养状况
Kai xuanji
compound manipulation“An Xian Cuo Mo”
Buhuanjin Zhengqi Powder
pediatric anorexia
gastrointestinal hormone
appetite-regulating factors
nutritional status
