摘要
目的 探讨经颅磁刺激联合药物干预在难治性精神分裂症患者中的治疗效果及对事件相关电位和认知功能的影响。方法 目的选取新疆石河子绿洲医院于2019年12月—2023年12月期间住院治疗的难治性精神分裂症患者300例为研究对象,并按照治疗方法不同分为观察组、对照组,其中对照组患者采取单一氨磺必利治疗,观察组患者联合应用经颅磁刺激处理,分析两组临床应用价值。结果 观察组临床疗效98.00%(147/150)优于对照组84.00%(126/150),差异有统计学意义(χ^(2)=17.949,P<0.05)。观察组治疗后完成分类数较对照组高,其余各维度评分均低于对照组,观察组治疗后靶潜伏期P3及N2较对照组下降,观察组治疗后社会功能评分较对照组提升,差异有统计学意义(P均<0.05)。结论 难治性精神分裂症患者采取经颅磁刺激与药物联合指导能够提高临床治疗效果,同时改善患者自身认知功能。
Objective To explore the therapeutic effect of transcranial magnetic stimulation combined with drug inter-vention in patients with refractory schizophrenia and its impact on event related potentials and cognitive function.Methods 300 patients with refractory schizophrenia who were hospitalized at Shihezi Oasis Hospital in Xinjiang from December 2019 to December 2023 were objectively selected as the research subjects and divided into an observation group and a control group by different treatment,with 150 each.Among them,the control group received single treat-ment with sulfamethoxide,and the observation group received combined treatment with transcranial magnetic stimula-tion.The clinical application value of the two groups was analyzed.Results The clinical efficacy of the observation group 98.00%(147/150)was better than 84.00%(126/150)of the control group,the difference was statistically signifi-cant(χ^(2)=17.949,P<0.05).The observation group had a higher number of completed classifications after treatment compared to the control group,and the scores of other dimensions were lower than the control group;the target latency P3 and N2 in the observation group were improved compared to the control group after treatment;and the social func-tion score in the observation group was improved compared to the control group after treatment,the differences were statistically significant(all P<0.05).Conclusion The combination of transcranial magnetic stimulation and medication guidance can improve the clinical treatment effect,cognitive function,and social function of patients with refractory schizophrenia.
作者
刘旭东
LIU Xudong(Xinjiang Shihezi Oasis Hospital,Shihezi 832000,Xinjiang Uygur Autonomous Region,China)
出处
《系统医学》
2024年第15期25-28,51,共5页
Systems Medicine
关键词
经颅磁刺激
药物干预
难治性精神分裂症
治疗效果
事件相关电位
认知功能
Transcranial magnetic stimulation
Drug intervention
Difficult to treat schizophrenia
Therapeutic effect
Event related potentials
Cognitive function
