摘要
目的探讨射波刀联合肝动脉化疗栓塞(TACE)术治疗原发性肝癌的临床疗效及对患者免疫功能和肿瘤标志物水平的影响。方法选取原发性肝癌患者92例,将患者随机分为观察组(46例)和对照组(46例)。观察组进行射波刀联合TACE治疗,对照组进行TACE治疗。比较2组治疗前后的免疫功能[免疫球蛋白A(IgA)、IgG、IgM]、肿瘤标志物水平[甲胎蛋白(AFP)、异常凝血酶原Ⅱ(PIVKA-Ⅱ)、γ谷氨酸转肽酶Ⅱ(GGT-Ⅱ)]、肝功能[谷丙转氨酶(ALT)、白蛋白、总胆红素(TBIL)],比较2组临床疗效及不良反应。结果治疗后,2组血清IgA、IgG及IgM水平均升高(P<0.05),且观察组高于对照组(P<0.05)。治疗后,2组血清AFP、GGT-Ⅱ、PIVKA-Ⅱ水平均降低(P<0.05),且观察组低于对照组(P<0.05)。治疗后,2组血清ALT、TBIL水平均降低(P<0.05),且观察组低于对照组(P<0.05);血清白蛋白水平均升高(P<0.05),且观察组高于对照组(P<0.05)。观察组有效率高于对照组(P<0.05);2组不良反应发生率比较无统计学差异(P>0.05)。结论射波刀联合TACE治疗原发性肝癌能够有效提高患者免疫功能,改善肝功能,抑制肿瘤标志物表达,疗效较好。
Objective To investigate the clinical efficacy of cyberknife combined with transcatheter arterial chemoembolization(TACE)in the treatment of primary liver cancer and the effects on immune function and tumor marker levels.Methods 92 patients with primary liver cancer were selected,and the patients were randomly divided into the observation group(46 cases)and the control group(46 cases).The observation group received cyberknife combined with TACE treatment,and the control group received TACE treatment.The immune function[immunoglobulin A(Ig)A,IgG,IgM],tumor marker levels[alpha-fetoprotein(AFP),γ-glutamyl transpeptidaseⅡ(GGT-Ⅱ),protein induced by vitamin K absence or antagonist-Ⅱ(PIVKA-Ⅱ)],liver function[alanine aminotransferase(ALT),albumin,total bilirubin(TBIL)]of the 2 groups were compared before and after treatment.The clinical efficacy and adverse reactions were compared between the 2 groups.Results After treatment,serum IgA,IgG and IgM levels increased in both groups(P<0.05),and the observation group was higher than the control group(P<0.05).After treatment,serum AFP,PIVKA-Ⅱand GGT-Ⅱlevels in the 2 groups were decreased(P<0.05),and the observation group was lower than the control group(P<0.05).After treatment,the levels of serum ALT and TBIL levels in 2 groups were decreased(P<0.05),and the observation group was lower than the control group(P<0.05).The levels of serum albumin levels were increased(P<0.05),and the observation group was higher than the control group(P<0.05).The effective rate of observation group was higher than that of control group(P<0.05).There was no difference in the incidence of adverse reactions between the 2 groups(P>0.05).Conclusion Cyberknife combined with TACE for primary liver cancer can effectively improve patients'immune function,liver function and inhibit the expression of tumor markers,the curative effect is better.
作者
王彦玲
张一平
高运红
王肖辉
WANG Yanling;ZHANG Yiping;GAO Yunhong(Zhengzhou Yihe Hospital,Zhengzhou,450000)
出处
《实用癌症杂志》
2024年第10期1635-1638,共4页
The Practical Journal of Cancer
基金
2021年度河南省医学科技攻关计划项目(编号:LHGJ20210348)。
关键词
射波刀
肝动脉化疗栓塞术
原发性肝癌
免疫功能
肿瘤标志物
Cyberknife
Hepatic artery chemoembolization
Primary liver cancer
Immune function
Tumor markers
