摘要
脑缺血-再灌注损伤(CIRI)是缺血性卒中患者恢复患侧脑组织血流时引发的严重并发症。CIRI患者常伴有神经功能减退、认知障碍、情绪障碍等,对日常生活产生严重影响。目前CIRI易被早期诊断,但相关特异性治疗方法相对较少。作者对环腺苷酸激活交换蛋白1/RAS相关蛋白1(Epac1/Rap1)信号通路与CIRI的相关性研究进行综述,以期为CIRI患者的临床治疗提供新思路。
Cerebral ischemia-reperfusion injury(CIRI)is a serious complication caused by the recovery of blood flow in the affected brain tissue of patients with ischemic stroke.CIRI patients are often accompanied by neurological dysfunction,cognitive impairment,emotional disorders and other symptoms,which have a serious impact on daily life.At present,CIRI is easy to be diagnosed early,but there are relatively few related specific treatments.In this paper,the correlation between cyclic adenylate-activated exchange protein 1/RAS-related protein 1(Epac1/Rap1)signaling pathway and CIRI is reviewed,in order to provide new ideas for clinical treatment of CIRI patients.
作者
吕雪
孙毅红
华志鹏
贾建新
Lyu Xue;Sun Yihong;Hua Zhipeng;Jia Jianxin(Graduate School of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014010,China)
出处
《中国脑血管病杂志》
CAS
CSCD
北大核心
2024年第8期552-558,共7页
Chinese Journal of Cerebrovascular Diseases
基金
国家自然科学基金(81860215)
内蒙古自治区自然科学基金(2021MS08010)。
