摘要
目的:对比分析自身免疫性胃炎与多灶萎缩性胃炎中医证型分布差异,为自身免疫性胃炎中医临床诊治提供参考依据。方法:纳入自身免疫性胃炎患者112例,采集患者一般资料及临床证候,确立中医证候分型,与本课题组既往252例多灶萎缩性胃炎证型分布研究比较,对中医证型相关性进行Logistic回归分析。结果:自身免疫性胃炎与多灶萎缩性胃炎中医证型分布均以脾胃虚弱证最多,其中自身免疫性胃炎肝胃气滞证、肝胃郁热证、胃阴不足证分布多于多灶萎缩性胃炎,脾胃湿热证、胃络瘀血证分布少于多灶萎缩性胃炎,二者差异有统计学意义(P<0.01)。经Logistic回归分析,肝胃气滞证与自身免疫性胃炎呈正相关(P<0.05),脾胃湿热证、胃络瘀血证与自身免疫性胃炎呈负相关(P<0.05)。结论:区别于多灶萎缩性胃炎,自身免疫性胃炎肝胃气滞证、肝胃郁热证分布较多,肝胃气滞与自身免疫性胃炎呈正相关关系,临床诊疗中更应重视肝这一病位因素及肝郁在其发生发展中的作用。
Objective:To analyze the difference in the distribution of traditional Chinese medicine(TCM)syndrome types between autoimmune gastritis and multifocal atrophic gastritis.To provide a reference for clinical diagnosis and treatment of autoimmune gastritis.Methods:A total of 112 patients were included in the study.Patients'general information and clinical symptoms were collected to establish TCM syndrome classification.The distribution of syndrome types in 252 cases of multifocal atrophic gastritis in previous research groups was compared with autoimmune gastritis.Logistic regression analysis was performed on the correlation between TCM syndrome types.Results:Both autoimmune gastritis and multifocal atrophic gastritis had the most distribution of spleen and stomach weakness syndrome.Autoimmune gastritis had more distribution of liver and stomach qi stagnation syndrome,liver and stomach depression-heat syndrome,and stomach yin insufficiency syndrome than multifocal atrophic gastritis,while had less distribution of spleen and stomach damp-heat syndrome and gastric luminal stasis syndrome than multifocal atrophic gastritis.The difference was statistically significant(P<0.01).Logistic regression showed liver and stomach qi stagnation syndrome was positively correlated with autoimmune gastritis(P<0.05).Spleen and stomach damp-heat syndrome and gastric luminal stasis syndrome were negatively correlated with autoimmune gastritis(P<0.05),respectively.Conclusion:Differing from multifocal atrophic gastritis,autoimmune gastritis had more distribution of liver and stomach qi stagnation syndrome and liver and stomach depression-heat syndrome than multifocal atrophic gastritis.Liver and stomach qi stagnation syndrome was positively correlated with autoimmune gastritis.We should pay more attention to the liver as a pathogenic factor and the role of hepatic depression in the occurrence and development of autoimmune gastritis in clinical diagnosis and treatment.
作者
刘景宇
赵晓琳
郭哲宇
周斌
LIU Jingyu;ZHAO Xiaolin;GUO Zheyu;ZHOU Bin(Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Beijing Shijingshan Traditional Chinese Medicine Hospital,Beijing 100043,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2024年第9期4976-4979,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金项目(No.82274505)。
关键词
自身免疫性胃炎
多灶萎缩性胃炎
证型分布
证型比较
Logistic回归分析
中医证型
Autoimmune gastritis
Multifocal atrophic gastritis
Distribution of syndrome types
Comparison of syndrome types
Logistic regression
Chinese medicine syndrome
