摘要
目的:探索中性粒细胞/淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)在肺炎支原体肺炎(Mycoplasma pneumoniae pneumonia,MPP)预后中的评估价值。方法:纳入2019年1月—2023年12月在徐州医科大学附属宿迁医院住院的2375例MPP患儿。根据病情将患儿分成重症肺炎支原体肺炎(severe Mycoplasma pneumoniae pneumonia,SMPP)组(n=125)和非SMPP组(n=2250)以及难治性肺炎支原体肺炎(refractory Mycoplasma pneumoniae pneumonia,RMPP)组(n=451)和非RMPP组(n=1924)。收集患儿基本资料及临床信息,回顾性分析NLR在SMPP及RMPP预后中评估价值。结果:NLR是独立预测SMPP的指标(OR=1.188,95%CI:1.123~1.299,P=0.033)。与低NLR组相比,高NLR组SMPP发生率更高(P<0.001)。NLR也是独立预测RMPP的指标(OR=1.320,95%CI:1.145~1.432,P<0.001)。高NLR组的SMPP发生率、RMPP发生率、ICU住院发生率、总发热时间、住院天数以及住院费用高于低NLR组(P<0.001)。结论:NLR可独立预测MPP患儿预后,为SMPP及RMPP的早期诊疗提供指导。
Objective:To explore the evaluation value of neutrophil to lymphocyte ratio(NLR)in the prognosis of Mycoplasma pneumoniae pneumonia(MPP).Methods:A retrospective analysis was applied to 2375 hospitalized children with MPP in Suqian Hospital Affiliated to Xuzhou Medical University from January 2019 to December 2023.According to the severity of the condition,the children were divided into severe MPP(SMPP)group(n=125)and non-SMPP group(n=2250),or into refractory MPP(RMPP)group(n=451)and non-RMPP group(n=1924).The basic information and clinical data of all pediatric patients were collected to assess the prognostic value of NLR in SMPP and RMPP.Results:NLR was an independent predictor of SMPP(OR=1.188,95%CI:1.123-1.299,P=0.033).Compared with children with a low NLR,children with a high NLR had a higher incidence of SMPP(P<0.001).NLR was also an independent predictor of RMPP(OR=1.320,95%CI:1.145-1.432,P<0.001).Children with a high NLR were more likely to develop SMPP and RMPP as well as had higher ICU hospitalization rate,total fever duration,longer hospital stays,and higher hospitalization costs,compared those with a low NLR(P<0.001).Conclusion:NLR may be used to independently predict the prognosis of MPP and provide guidance for early treatment of SMPP and RMPP.
作者
蒋亚洲
刘峰
JIANG Yazhou;LIU Feng(Department of Respiration,Children’s Hospital of Nanjing Medical University,Nanjing 210008;Department of Pediatrics,Suqian Hospital Affiliated to Xuzhou Medical University,Suqian 223800,China)
出处
《南京医科大学学报（自然科学版）》
CAS
北大核心
2024年第10期1383-1389,共7页
Journal of Nanjing Medical University(Natural Sciences)
基金
国家自然科学基金(82270008)
宿迁市科技局科技计划项目(K202118)。
关键词
中性粒细胞/淋巴细胞比值
肺炎支原体肺炎
重症肺炎支原体肺炎
难治性肺炎支原体肺炎
预后
neutrophil to lymphocyte ratio
Mycoplasma pneumoniae pneumonia
severe Mycoplasma pneumoniae pneumonia
refractory Mycoplasma pneumoniae pneumonia
prognosis
