摘要
目的:探讨藻酸盐敷料联合黄连膏用于痔术后的临床效果。方法:选取2022年1月-2023年9月中国人民解放军92493部队医院收治的100例痔手术患者,并按随机数字表法分成敷料组(n=50,术后应用藻酸盐敷料治疗)和联合组(n=50,术后应用藻酸盐敷料联合黄连膏治疗)。比较两组临床疗效、疼痛状况、血清血管内皮生长因子(VEGF)及成纤维细胞生长因子-1(FGF-1)水平、肛肠动力学指标及创面情况。结果:联合组总有效率为96.00%,优于敷料组的83.33%(P<0.05);组间和时间在NRS评分上的主效应比较有差异(P<0.05),且存在交互作用(P<0.05),联合组术后3 d、1周、2周及3周NRS评分较敷料组更低(P<0.05);术后3周,两组血清VEGF、FGF-1水平均高于术后1 d(P<0.05),且联合组均高于敷料组(P<0.05);术后3周,两组直肠最大耐受容量(MTV)、肛管最大收缩压(MSP)均高于术前(P<0.05),且联合组均高于敷料组(P<0.05);联合组创面水肿消失、创面愈合时间也短于敷料组(P<0.05)。结论:痔手术后应用藻酸盐敷料联合黄连膏治疗的效果更佳,可明显提高血清VEGF、FGF-1水平,显著改善肛肠动力学及疼痛指标,有效促进创面水肿消失及创面愈合。
Objective To explore the effects of alginate dressing combined with Huanglian ointment on postoperative hemorrhoid surgery.Methods A total of 100 patients undergoing hemorrhoid surgery admitted to the 92493 Unit Hospital of the Chinese People's Liberation Army from January 2022 to September 2023 were collected and randomly grouped into a dressing group(n=50,treated with alginate dressing after surgery)and a study group(n=50,treated with alginate dressing combined with Huanglian ointment after surgery)using a random number table method.The efficacy,pain status[evaluated using a numerical evaluation scale(NRS)],serum indicators[vascular endothelial growth factor(VEGF)and fibroblast growth factor-1(FGF-1)],anorectal motility indicators[maximum rectal tolerance volume(MTV),maximum anal systolic pressure(MSP)],and wound conditions were compared between the two groups.Results The total effective rate of the study group was 96.00%,which was higher than 83.33%in the dressing group(P<0.05);there were differences in the main effects of NRS scores among groups and time(P<0.05),and there was an interaction effect(P<0.05),the NRS scores of the study group were lower than those of the dressing group at 3 days,1 week,2 weeks,and 3 weeks after surgery(P<0.05);three weeks after surgery,the levels of serum VEGF and FGF-1 in both groups were higher than those on the first day after surgery(P<0.05),and the study group were higher than the dressing group(P<0.05);three weeks after surgery,the MTV and MSP of both groups were higher than before surgery(P<0.05),and the study group were higher than the dressing group(P<0.05);the time of wound edema disappearing and wound healing in the study group shorter than the dressing group(P<0.05).Conclusion The use of alginate dressing combined with Huanglian ointment after hemorrhoid surgery has a better effect,it can obviously increase the levels of serum VEGF and FGF-1,obviously improve anal motility and pain,and effectively promote the disappearance of wound edema and wound healing.
作者
马德华
孙晓坤
李云鹏
曹丹
王霖
MA De-hua;SUN Xiao-kun;LI Yun-peng(Department of Outpatient,Chinese People's Liberation Army 92493 Unit Hospital,Huludao 125000,China)
出处
《中国中西医结合外科杂志》
CAS
2024年第5期666-670,共5页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
基金
国家自然科学基金(81803860)。
关键词
藻酸盐敷料
黄连膏
痔
疼痛
创面愈合
Alginate dressing
Huanglian ointment
hemorrhoids
pain
wound healing
