摘要
随着对免疫检查点研究的不断发展,通过阻断免疫检查点对肿瘤进行靶向治疗已成为肿瘤治疗的重要手段之一。T细胞免疫球蛋白黏蛋白3(TIM-3)作为负性免疫检查点,与其配体半乳糖凝集素9(Gal-9)的结合已在多种癌症中被证明可促进肿瘤免疫逃逸。在血液、消化、呼吸系统肿瘤中,通过阻断TIM-3/Gal-9影响不同信号通路,调节机体T细胞、B细胞、树突状细胞、自然杀伤细胞、单核/巨噬细胞生长,抑制调节性T细胞发挥抗肿瘤作用。TIM-3抗体作为免疫检查点抑制剂在分子靶向抗肿瘤中具有潜在的治疗价值。文中总结了靶向TIM-3/Gal-9在多种癌症的肿瘤微环境中抗肿瘤的作用机制。
With the ongoing advancement of immune checkpoint research,targeting tumors through immune checkpoint blockade has emerged as a crucial approach in cancer therapy.T cell immunoglobulin and mucin-domain containing protein 3(TIM-3)functions as a negative immune checkpoint.It has been demonstrated that the interaction of TIM-3 with its ligand galectin-9(Gal-9)can promote immune escape in a variety of cancers.In hematologic,digestive,and respiratory tumors,it affects different signaling pathways by blocking TIM-3/Gal-9 interaction,thereby regulating the growth of T cells,B cells,dendritic cells,NK cells,and monocytes/macrophages,and inhibiting regulatory T cells to exert anti-tumor effects.TIM-3 antibodies have potential therapeutic value as immune checkpoint inhibitors in molecularly-targeted anti-tumor therapy.This article reviews the mechanisms of anti-tumor effects of TIM-3/Gal-9 in the tumor microenvironment of various cancers.
作者
马澜馨
白丽
MA Lanxin;BAI Li(School of Basic Medical Sciences,Dali University,Dali 671000,China;Yunnan Key Laboratory for Biomedical Research and Development of Insects,Dali University,Dali 671000,China)
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2024年第8期754-760,共7页
Chinese Journal of Cellular and Molecular Immunology
基金
国家自然科学基金(81360319)
云南省2019年中药饮片产业发展专项资金(2019-YG-067)。