摘要
目的探讨分析碘解磷定联合长托宁治疗对有机磷农药中毒(AOPP)患者外周血中性粒细胞-淋巴细胞比值(NLR)、血乳酸(LAC)、CHE(胆碱酯酶)水平的影响。方法选取2019年1月至2023年1月六安世立医院重症医学科收治的有机磷农药中毒患者合计100例,随机分为对照组及联合组各50例,两组均给予常规急诊治疗和长托宁进行治疗,联合组在前者基础上联合碘解磷定进行治疗。比较两组临床疗效、CHE拐点时间、中毒症状消失时间、机械通气时间和平均住院时间;比较两组治疗前后外周血NLR、LAC、CHE表达情况及心肌酶谱[乳酸脱氢酶(LD)、肌酸激酶(CK)]及肝功能[谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)]水平。结果治疗后,联合组临床疗效高于对照组,差异有统计学意义(χ^(2)=4.396,P<0.05);联合组CHE拐点时间、中毒症状消失时间、机械通气时间、平均住院时间较对照组均有缩短,差异有统计学意义(t=3.882,4.629,2.065,4.339,P<0.05);治疗后,两组外周血CHE水平较治疗前均明显升高且联合组升高更明显,NLR、LAC则明显降低且联合组下降更明显,差异有统计学意义(t=7.949,5.091,4.647,P<0.05);治疗后,两组LD、CK及TBIL、ALT、AST较治疗前均明显下降且联合组下降更明显,差异有统计学意义(t=3.568,4.469,4.894,3.447,5.896,P<0.05)。结论碘解磷定联合长托宁可有效改善AOPP患者外周血LAC、CHE、NLR表达,临床疗效确切。
Objective To investigate the effects of proxime iodide combined with changtonine therapy on peripheral blood neutrophil-lymphocyte ratio(NLR),blood lactic acid(LAC)and CHE(cholines-terase)levels in patients with organophosphorus pesticide poisoning(AOPP).Methods A total of 100 pa-tients with organophosphorus pesticide poisoning were admitted to the Intensive Care Department of Luan World Health Hospital from January 2019 to January 2023.They were randomly divided into two groups:a control group and a combined group,each with 50 cases.Both groups received routine emergency treatment and changtonine treatment,and the combined group also received pralidoxime iodide treatment in addition to the former.The clinical efficacy,CHE inflection point time,toxic symptom disappearance time,mechanical ventilation time and average hospital stay were compared between the two groups.The expression of NLR,LAC,and CHE in peripheral blood,myocardial enzyme profile[lactate dehydrogenase(LD),creatine kinase(CK)]and liver function[ALT),AST and total bilirubin(TBIL)]were compared before and after treatment in both groups.Results After treatment,the clinical efficacy of the combined group was higher than that of the control group,with statistical significance(χ^(2)=4.396,P<0.05).The inflection point time for CHE,toxic symptom disappearance time,mechanical ventilation time and average hospital stay in the combined group were significantly shorter than those in the control group,with statistical significance(t=3.882,4.629,2.065,4.339,P<0.05).After treatment,the CHE level in peripheral blood of both groups was significantly higher than before treatment,and the increase was more obvious in the combination group.Meanwhile,NLR and LAC were significantly decreased and the decrease was more obvious in the combination group,with statistical significance(t=7.949,5.091,4.647,P<0.05).Furthermore,after treatment,LD,CK,TBIL,ALT,and AST levels in both groups significantly decreased compared to before treatment,and the decrease was more obvious in the com-bined group,with statistical significance(t=3.568,4.469,4.894,3.447,5.896,P<0.05).Conclusion Prali-doxime iodide combined with changtoxide can effectively enhance the expression of LAC,CHE,and NLR in the peripheral blood of patients with AOPP.
作者
吴庆龙
周兆杰
黄文彪
WU Qingong;ZHOU Zhaojie;HUANG Wenbiao(Department of Critical Care Medicine,Lu'an Shi National Hospital,Lu'an,Anhui,China,237010)
出处
《分子诊断与治疗杂志》
2024年第9期1683-1686,共4页
Journal of Molecular Diagnostics and Therapy
基金
安徽省重点研究和开发计划项目(180408020267)。
