摘要
RNA interference(RNAi)is a fascinating biological process in worms,plants,fungi,and metazoans that has been used as a valuable tool in studying gene functions and as therapeutics.In Caenorhabditis elegans,the multipass transmembrane protein,systemic RNA interference defective protein 1(SID-1),has an indispensable role in the uptake and spreading of double-stranded RNA(dsRNA)between cells and tissues,resulting in systemic RNAi.
基金
supported by the National Natural Science Foundation of China
IOP
CAS
