摘要
目的探讨无并发症双绒毛膜(dichorionic,DC)和单绒毛膜(monochorionic,MC)双胎妊娠孕妇血流动力学的改变,从而更好地进行产前监护。方法选取2020年5月至2021年9月复旦大学附属妇产科医院无并发症双胎妊娠孕妇64例(41例DC和23例MC),另选取同期无并发症单胎妊娠孕妇144例作为对照组。孕妇于孕中期(20~28周)行常规超声心动图检查,单胎妊娠孕妇作为对照,对DC和MC双胎妊娠孕妇进行左室收缩、左室舒张、血流动力学和心脏结构参数的研究。结果在孕20~28周,与单胎妊娠比较,双胎妊娠孕妇的心率、平均动脉压、心输出量、心脏指数、每搏输出量、左心室质量、每搏输出功显著增加,总血管阻力显著降低,差异均存在统计学意义(P<0.05)。DC和MC双胎妊娠孕妇的血流动力学参数分布相似。与DC相比,MC双胎妊娠孕妇的心输出量显著增加(5.76 L/min vs.5.36 L/min,P=0.031),总血管阻力显著降低(1270 vs.1407,P=0.037)。结论与单胎妊娠相比,双胎妊娠孕妇血流动力学发生显著变化,为胎儿的生长发育提供了足够的子宫胎盘循环。DC和MC双胎妊娠孕妇的心血管适应模式相似,但MC双胎妊娠孕妇的心输出量更高,总血管阻力更低。对双胎妊娠尤其是MC双胎孕妇心脏功能的监护对于孕妇的安全至关重要。
Objective To explore the changes of hemodynamics in pregnant women with uncomplicated dichorionic(DC)twin pregnancy and monochorionic(MC)twin pregnancy,so as to better perform prenatal monitoring.Methods A study was conducted to collect 64 pregnant women with uncomplicated twin pregnancy(41 cases of DC and 23 cases of MC)in the Obstetrics and Gynecology Hospital,Fudan University from May 2020 to Sept 2021,and 144 pregnant women with uncomplicated singleton pregnancies in the same period were selected as the control group.During the second trimester(20-28 weeks),conventional echocardiography was performed in pregnant women,and singleton pregnancy was used as the control.The left ventricular systolic,left ventricular diastolic,hemodynamic and cardiac structural parameters of DC and MC twin pregnancy were studied.Results At 20-28 weeks of gestation,compared with singleton pregnancies,the heart rate,mean arterial pressure,cardiac output,cardiac index,stroke volume,left ventricular mass,stroke work index parameters of twin pregnancy were significantly increased,and the total vascular resistance was significantly decreased,and the differences were statistically significant(P<0.05).The distribution of maternal hemodynamic parameters was similar in pregnant women with DC twin and MC twin pregnancy.Compared with DC twin pregnancy,MC twin pregnancy showed a significant increase in cardiac output(5.76 L/min vs.5.36 L/min,P=0.031).Total vascular resistance significantly decreased(1270 vs.1407,P=0.037).Conclusion Compared with singleton pregnancy,the hemodynamics of twin pregnancy significantly changed,which ensured the growth and development of the fetus by providing sufficient uteroplacental circulation.The cardiovascular adaptation patterns of DC and MC twin pregnancy were similar,but MC twin pregnancy had higher cardiac output and lower total vascular resistance.Monitoring the cardiac function of twin pregnancy,especially MC twin pregnancy,is very important for the safety of pregnant women.
作者
蔡琪
吴淑道
项金莲
任芸芸
CAI Qi;WU Shu-dao;XIANG Jin-lian;REN Yun-yun(Department of Ultrasound,Obstetrics and Gynecology Hospital,Fudan University,Shanghai 200011,China)
出处
《复旦学报（医学版）》
CAS
CSCD
北大核心
2024年第5期718-724,共7页
Fudan University Journal of Medical Sciences
