摘要
放射治疗是肺癌治疗的重要手段,然而肺部肿瘤随呼吸运动产生的空间运动,对精准放疗提出了挑战。针对目前精准放射治疗中图像引导带来的对健康组织的额外辐射剂量问题,本文提出一种利用仿肺软体驱动器体外模拟肺的呼吸变形运动,通过建模预测肺部肿瘤运动的思路,从而减少患者接受额外辐射剂量,实现精准并安全的放射治疗。首先利用CT图像精准完成肺部的外形还原,然后得到的肺部随呼吸的变形运动规律。在此基础上,设计了肺部空腔的形态,并通过变形仿真验证了结构设计的合理性,据此制作了仿肺软体驱动器样机。最后,通过给予离散化的周期性气压来模拟实际的呼吸状态对样机进行了测试。实验结果表明:所设计仿肺软体驱动器可以按预期完成呼吸变形模拟,最大气压为45 kPa,最大轴向位移为5.9 mm,最大径向位移为3.4 mm。仿肺软体驱动器具有良好的呼吸运动变形模拟效果,可以为肺部肿瘤精准安全放射治疗提供借鉴。
Radiation therapy stands as a crucial method in treating lung cancer.However,the spatial movement of lung tumor by the respiratory movement presents challenge to precision radiotherapy.Aiming at the problem of extra radiation doses to healthy tissues caused by image guidance in current precision radiation therapy,this paper proposes an idea to simulate the respiratory deformation of the lungs in vitro by using a lung-like soft actuator.By modeling and predicting the motion of lung tumors,this approach aims to reduce the additional radiation dose to patients,thereby achieving accurate and safe radiation therapy.Firstly,the CT imaging is used to reconstruct the lung′s shape accurately,capturing the deformation motion pattern of the lungs during respiration.On this basis,the morphology of the lung cavity is designed and the structural design′s feasibility is verified through deformation simulation.A prototype of the lungmimicking soft actuator is then developed.Finally,the prototype is tested by giving discrete periodic air pressure to simulate the actual respiratory process.The experimental results show that the designed lung-like soft actuator can simulate respiration deformation as expected,with the maximum air pressure of 45 kPa,the maximum axial displacement of 5.9 mm,and the maximum radial displacement of 3.4 mm.The soft actuator exhibits good deformation mimics performance,and can be used as a reference of accurate and safe radiation therapy for lung tumors.
作者
张来喜
文伟韬
孟文强
徐丰羽
马凯威
Zhang Laixi;Wen Weitao;Meng Wenqiang;Xu Fengyu;Ma Kaiwei(School of Mechanical and Electrical Engineering,Lanzhou University of Technology,Lanzhou 730050,China;College of Automation,Nanjing University of Posts and Telecommunications,Nanjing 210046,China)
出处
《仪器仪表学报》
EI
CAS
CSCD
北大核心
2024年第7期176-188,共13页
Chinese Journal of Scientific Instrument
基金
国家自然科学基金(52265013)项目资助。
关键词
仿肺软体驱动器
逆向建模
呼吸运动
变形控制
lung-like soft actuator
reverse modeling
respiratory motion
deformation control
