摘要
目的 观察麦角新碱联合肝素治疗急诊胎盘早剥的效果,及对母婴结局的影响。方法 本文为前瞻性研究,纳入焦作市妇幼保健院2020年1月至2022年12月收治的119例胎盘早剥患者,采用电脑随机分组法分为观察组(60例)和对照组(59例)。对照组采用肝素治疗,观察组在对照组治疗基础上,加用麦角新碱配合治疗。比较两组产妇的产程时间、产后出血情况、实验室指标,以及对应新生儿的凝血指标、临床结局。结果 两组第一产程、第二产程时间差异无统计学意义(P>0.05);但观察组第三产程时间低于对照组,差异有统计学意义(P<0.05)。观察组产后出血时间、产后出血量均低于对照组,差异有统计学意义(P<0.05)。观察组产后15 min、30 min、60 min的血红蛋白(Hb)均高于对照组,差异有统计学意义(P<0.05)。观察组中新生儿的凝血酶原时间(PT)低于对照组;纤维蛋白原(FIB)高于对照组,差异有统计学意义(P<0.05)。观察组内新生儿娩出后24 h内、48 h内的弥散性血管内凝血(DIC)发生率均低于对照组,差异有统计学意义(P<0.05)。结论 麦角新碱联合肝素治疗急诊胎盘早剥能有效缩短产妇第三产程并降低产后出血风险,对改善新生儿的凝血功能并降低DIC发生风险均有积极作用。
Objective Observe the effect of ergoxine combined with heparin in the treatment of emergency placental abruption and its impact on maternal and infant outcomes.Methods This article was a prospective study,119 patients admitted to Jiaozuo Maternal and Child Health Hospital from January 2020 to December 2022 with placental abruption were randomly divided into an observation group(60 cases)and a control group(59 cases)using computer randomization.The control group was treated with heparin,the observation group was treated with ergometrine on the basis of the control group.Compare the duration of labor,postpartum bleeding,laboratory indicators,coagulation indicators and clinical outcomes of premature infants between two groups.Results The first and second stages of labor were similar in both groups of patients(P>0.05);the third stage of labor time in the observation group was lower than that in the control group.The postpartum bleeding time and a postpartum bleeding volume in the observation group were lower than those in the control group(P<0.05).The Hb in the observation group were higher than those in the control group at 15,30,60 minutes postpartum(P<0.05).The PT of premature infants in the observation group was lower than that in the control group;FIB was higher than in the control group(P<0.05).The incidence of disseminated intravascular coagulation within 24,48 hours after delivery of premature infants in the observation group were lower than those in the control group(P<0.05).Conclusion The combination of ergometrine and heparin in the treatment of placental abruption can effectively shorten the third stage of labor and reduce the risk of postpartum bleeding.It has a positive effect on improving the coagulation function of premature infants and reducing the risk of disseminated intravascular coagulation.
作者
赵冰冰
ZHAO Bingbing(Jiaozuo Maternal and Child Health Hospital,Jiaozuo Henan 454000,China)
出处
《药品评价》
CAS
2024年第6期742-745,共4页
Drug Evaluation
基金
河南省医学科技攻关项目(LHGJ202102461)。
关键词
胎盘早剥
麦角新碱
肝素注射液
母婴结局
弥散性血管内凝血
Placental abruption
Ergoxine
Heparin injection
Maternal and infant outcomes
Disseminated intravascular coagulation
