摘要
目的探究理肺解毒益髓汤对晚期肺癌化疗增效减毒作用及对中医证候积分、细胞因子和免疫功能的影响。方法选择河北省石家庄第八医院2020年6月—2022年7月接受化疗的102例肺癌晚期患者,以随机数表法分为治疗组51例,对照组51例。治疗周期结束时评价两组临床疗效,并于治疗前、治疗周期结束时比较两组中医证候积分、细胞因子、免疫功能、生活质量及安全性。结果治疗周期结束后,治疗组客观缓解率(ORR)为54.90%,高于对照组的35.29%(P<0.05)。两组中医证候积分较治疗前下降,治疗组低于对照组(P<0.05)。两组白细胞介素-2(IL-2)、干扰素-γ(IFN-γ)水平较治疗前上升,白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、肿瘤坏死因子(TNF-α)水平较治疗前下降,治疗组IL-2、IFN-γ、TNF-α高于对照组(P<0.05),IL-6、IL-10低于对照组(P<0.05)。两组CD_(3)^(+)、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)、NK水平较治疗前上升,CD_(8)^(+)水平较治疗前下降,治疗组CD_(3)^(+)、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)、NK高于对照组(P<0.05),CD_(8)^(+)低于对照组(P<0.05)。治疗组肺癌患者生活质量评价量表(FACT-L)评分较治疗前上升,对照组FACT-L评分较治疗前下降,治疗组FACT-L各维度评分均高于对照组(P<0.05)。两组恶心呕吐、血小板减少、骨髓抑制、失眠等不良反应差异有统计学意义(P<0.05)。结论理肺解毒益髓汤辅助治疗晚期肺癌化疗患者有良好的增效减毒作用,有助于降低中医证候积分,改善机体免疫功能。
Objective To investigate the effect-enhancing and toxic-reducing role of Lifei Jiedu Yisui Decoction(理肺解毒益髓汤)in chemotherapy for advanced lung cancer,and the influence on TCM syndrome scores,cytokines and immune function.Methods A total of 102 patients with advanced lung cancer who underwent chemotherapy in the Shijiazhuang Eighth Hospital from June 2020 to July 2022 were selected and divided into a treatment group(51 cases)and a control group(51 cases)by random number table method.Clinical effects in the two groups were evaluated.TCM syndrome scores,cytokines,immune function,quality of life and safety were compared between the two groups.Results After treatment,the objective response rate(ORR)in the treatment group(54.90%)was higher than that in the control group(35.29%)(P<0.05).TCM syndrome scores of the two groups decreased,and the treatment group had lower scores than the control group(P<0.05).The levels of interleukin-2(IL-2)and interferon-γ(IFN-γ)in the two groups increased,and the levels of interleukin-6(IL-6),interleukin-10(IL-10)and tumor necrosis factor(TNF-α)decreased.The levels of IL-2,IFN-γand TNF-αin the treatment group were higher than those in the control group.The levels of IL-6 and IL-10 were lower than those in the control group(P<0.05).The levels of CD_(3)^(+),CD_(4)^(+),CD_(4)^(+)/CD_(8)^(+)and natural killer(NK)cells in the two groups increased,and the levels of CD_(8)^(+)decreased.The levels of CD_(3)^(+),CD_(4)^(+),CD_(4)^(+)/CD_(8)^(+)and NK cells in the treatment group were higher than those in the control group(P<0.05),and the level of CD_(8)^(+)was lower than that in the control group(P<0.05).The Functional Assessment of Cancer Therapy-Lung(FACT-L)scale scores of the treatment group increased,and were higher than those of the control group(P<0.05).There were significant differences in adverse reactions such as nausea and vomiting,thrombocytopenia,bone marrow suppression and insomnia between the two groups(P<0.05).Conclusion Lifei Jiedu Yisui Decoction plays a good effect-enhancing and toxic-reducing role in chemotherapy for advanced lung cancer.It is helpful to reduce TCM syndrome scores and improve immune function.
作者
赵宣
闫红倩
裴玉蓁
ZHAO Xuan;YAN Hongqian;PEI Yuzhen(Shijiazhuang Eighth Hospital,Shijiazhuang 050000,Hebei,China;Hebei Provincial Hospital of Traditional Chinese Medicine,Shijiazhuang 050011,Hebei,China)
出处
《辽宁中医杂志》
CAS
北大核心
2024年第10期116-120,共5页
Liaoning Journal of Traditional Chinese Medicine
基金
河北省中医药管理局科研计划项目(2021088)。
关键词
肺癌
晚期
化疗
理肺解毒益髓汤
增效减毒
lung cancer
advanced period
chemotherapy
Lifei Jiedu Yisui Decoction
effect-enhancing and toxic-reducing
