摘要
目的研究罂粟乙碘油用于不孕人群子宫输卵管造影的影像诊断质量和助孕作用。方法选取2020年1月—2022年12月在湖州市妇幼保健院治疗的不孕患者120例为研究对象,分组方法为随机数表法,将研究对象分为对照组(碘海醇,60例)和观察组(罂粟乙碘油,60例),比较两组影像诊断质量、疼痛、不良反应及自然妊娠情况。结果与对照组(2.00±0.45)分、(2.03±0.41)分、(1.60±0.49)分、(2.15±0.71)分及(2.00±0.45)分比较,观察组腹腔内分布评分(2.25±0.44)分、输卵管溢出评分(2.63±0.49)分、Fimbrial皱褶评分(2.10±0.44)分、输卵管形态评分(2.57±0.50)分、子宫不透明度/轮廓评分(2.20±0.40)分更高,差异均有统计学意义(t=3.085、7.307、5.857、3.721及2.560,均P<0.05)。整体比较,两组脸谱法疼痛评估(FPS-R)评分的时点因素比较,差异有统计学意义(P<0.05);与对照组(2.33±0.70)分、(1.91±0.56)分、(1.64±0.37)分及(1.04±0.16)分比较,观察组术后1 d的FPS-R评分(2.16±0.75)分、3 d的FPS-R评分(1.90±0.59)分、5 d的FPS-R评分(1.59±0.33)分及7 d的FPS-R评分(1.03±0.21)分比较,差异均无统计学意义(t=-1.622、-0.397、-0.546及-1.031,均P>0.05)。观察组不良反应发生率(63.33%)低于对照组(93.33%),差异有统计学意义(χ^(2)=12.102,P<0.05)。观察组术后3个月自然妊娠率(23.33%vs.16.67%)、术后6个月自然妊娠率(28.33%vs.20.00%)及术后12个月的自然妊娠率(38.33%vs.28.33%)与对照组比较,差异均无统计学意义(χ^(2)=0.833、1.137及1.350,均P>0.05)。结论罂粟乙碘油用于不孕人群子宫输卵管造影的影像诊断质量更好,且能够减少不良反应,其助孕作用和碘海醇相当。
Objective The research explores the efficacy of ethiodized poppyseed oil as a contrast agent in hysterosalpingography for enhancing diagnostic imaging quality and facilitating fertility assessment among individuals experiencing infertility.Methods Between January 2020 and December 2022,a study was conducted at Huzhou Maternal and Child Health Hospital involving 120 patients experiencing infertility.These participants were randomly allocated into two groups:a control group of 60 patients who received iodixanol and an observation group of 60 patients administered ethiodized poppyseed oil.The investigation focused on comparative assessments of image diagnostic quality,patient-reported pain,adverse reactions,and rates of natural conception between the two groups.Results Compared to the control group scores of(2.00±0.45),(2.03±0.41),(1.60±0.49),(2.15±0.71),and(2.00±0.45),the observation group exhibited significantly higher scores in intraperitoneal distribution(2.25±0.44),tubal spillage(2.63±0.49),fimbrial folding(2.10±0.44),tubal morphology(2.57±0.50),and uterine opacity/contour(2.20±0.40)(t=3.085,7.307,5.857,3.721,2.560,all P<0.05).While the comparison of the Facial Pain Scale-Revised(FPS-R)scores between the two groups across different time points showed a statistically significant overall difference(P<0.05),the specific FPS-R scores on postoperative day 1(2.16±0.75),day 3(1.90±0.59),day 5(1.59±0.33),and day 7(1.03±0.21)in the observation group did not differ significantly from the control group scores of(2.33±0.70),(1.91±0.56),(1.64±0.37),and(1.04±0.16)(t=-1.622,-0.397,-0.546,-1.031,all P>0.05).The incidence of adverse reactions was significantly lower in the observation group(63.33%)compared to the control group(93.33%)(χ^(2)=12.102,P<0.05).The natural pregnancy rates at 3 months(23.33%vs.16.67%),6 months(28.33%vs.20.00%),and 12 months(38.33%vs.28.33%)postoperatively did not show statistically significant differences between the observation and control groups(χ^(2)=0.833,1.137,1.350,all P>0.05).Conclusion Ethiodized poppyseed oil,when utilized in hysterosalpingography for the infertile population,enhances diagnostic image quality and decreases adverse reactions,demonstrating fertility assistance efficacy comparable to that of iodixanol.
作者
曹单
蒋敏华
徐飞鹤
张甦
CAO Dan;JIANG Min-hua;XU Fei-he;ZHANG Su(Departmen of Gynaecology,Huzhou Maternity and Child Care Hospital,Huzhou,Zhejiang 313000,China)
出处
《中国妇幼保健》
CAS
2024年第18期3537-3540,共4页
Maternal and Child Health Care of China
基金
浙江省湖州市科学技术局项目(2021GYB2)。
关键词
罂粟乙碘油
不孕
子宫输卵管造影
影像诊断质量
助孕
Ethiodized poppyseed oil
Infertility
Hysterosalpingography
Diagnostic image quality
Fertility assistance