摘要
目的 了解孤独症谱系障碍(ASD)儿童血清25-羟维生素D[25(OH)D]水平和情绪社会功能的关系,为ASD儿童综合干预提供参考依据。方法 2024年1—6月,选取南通市定点康复机构康复训练的124名1~3岁ASD儿童纳入病例组,同时选取同期健康体检的124名性别、年龄相匹配的健康儿童纳入对照组。采用液质联用法测定两组儿童血清25(OH)D水平,采用中国幼儿情绪及社会性发展量表(CITSEA)评估ASD儿童情绪社会化功能,并探讨血清25(OH)D水平与情绪社会功能的关系。结果 病例组儿童的血清25(OH)D水平[(59.22±19.96)nmol/L]低于对照组[(85.50±21.59)nmol/L],25(OH)D不足或缺乏率(21.77%)高于对照组(7.26%),差异均有统计学意义(t/χ^(2)值分别为-7.75,8.91,P值均<0.01)。CITSEA评估结果显示,ASD儿童外显行为域、内隐行为域、失调域和能力域得分分别为(63.37±10.44,56.29±9.36,57.04±10.65,38.92±17.91)分,各维度异常检出率分别为50.81%,35.48%,41.13%,45.16%。其中男童外显行为域、能力域异常检出率(57.14%,51.02%)均高于女童(34.62%,23.08%),差异均有统计学意义(χ^(2)值分别为4.18,6.48,P值均<0.05)。血清25(OH)D不足或缺乏组ASD儿童外显行为域、失调域异常检出率(77.78%,59.26%)均高于血清25(OH)D正常组(37.11%,18.56%),差异均有统计学意义(χ^(2)值分别为14.06,17.58,P值均<0.01)。结论 ASD儿童血清25(OH)D水平明显低于健康儿童,且普遍存在情绪社会功能发育异常。
Objective To understand the relationship between serum 25 hydroxyvitamin D[25(OH)D]levels and social-emotional functions in children with autism spectrum disorder(ASD),in order to provide the reference for comprehensive interventions in ASD children.Methods From January to June 2024,124 ASD children aged 1-3 who received rehabilitation training at designated rehabilitation institutions in Nantong City,China were selected as the case group,while 124 healthy gender-and age-matched children who underwent health examinations at the same time were selected as the control group.The study used liquid chromatography-mass spectrometry to measure serum 25(OH)D levels in both groups of children.The Chinese Infant-Toddler Social and Emotional Assessment(CITSEA)was used to evaluate the emotional and socialization functioning of children with ASD,and to explore the relationship between serum 25(OH)D levels and their emotional and social functioning.Results The serum 25(OH)D levels were lower in the case group[(59.22±19.96)nmol/L]compared to the control group[(85.50±21.59)nmol/L],and the rate of 25(OH)D deficiency or insufficiency(21.77%)was higher than that of the control group(7.26%),with statistically significant differences(t/χ^(2)=-7.75,8.91,P<0.01).The CITSEA evaluation results showed that the scores of the explicit behavior domain,implicit behavior domain,dysregulation domain,and ability domain in children with ASD were(63.37±10.44,56.29±9.36,57.04±10.65,38.92±17.91)points,and the abnormal detection rates were 50.81%,35.48%,41.13%,and 45.16%,respectively.Among them,the abnormal detection rates of the explicit behavior domain and ability domain were higher in boys(57.14%,51.02%)compared to girls(34.62%,23.08%),and the differences were statistically significant(χ^(2)=4.18,6.48,P<0.05).The abnormal detection rates of explicit behavioral domains and dysregulated domains in ASD children with insufficient or deficient serum 25(OH)D(77.78%,59.26%)were higher than those in the normal serum 25(OH)D group(37.11%,18.56%),and the differences were statistically significant(χ^(2)=14.06,17.58,P<0.01).Conclusion The serum 25(OH)D levels in children with ASD are significantly lower compared to levels in healthy children,and developmental abnormalities in social-emotional functioning are common concurrent problems.
作者
许占斌
王飞英
秦宏超
陶小冬
瞿秋婵
倪勇
XU Zhanbin;WANG Feiying;QIN Hongchao;TAO Xiaodong;ZHAI Qiuchan;NI Yong(Child Health Section,Affiliated Maternity and Child Health Care Hospital of Nantong University,Nantong(226018),Jiangsu Province,China;不详)
出处
《中国学校卫生》
CAS
北大核心
2024年第9期1242-1245,共4页
Chinese Journal of School Health
基金
南通市卫生健康委面上项目(MS2022075,MSZ2023058)
南通市科技局社会民生科技计划项目(MSZ2023011)。
