摘要
老年期痴呆是在老年人群中发病率较高的疾病,对患者本人、患者家庭带来极大的负担,也对社会造成沉重的经济压力。小胶质细胞是中枢系统中的一种免疫细胞,在老年期痴呆的病程发展中存在“双刃剑”的作用。本文将阐述衰老对小胶质细胞的影响,并从老年期痴呆中常见的阿尔茨海默病、血管性痴呆及帕金森病痴呆等疾病探讨小胶质细胞激活所产生的保护、破坏作用。大量的研究证实,中医药能够通过对小胶质细胞的调控,干预并改善老年期痴呆的病程进展,且有着多靶点、多通路的优势。
Senile dementia is a disease with a high incidence rate among the elderly,which brings great burden to the patients themselves and their families,and also brings heavy economic pressure to the society.Microglia are a type of immune cell in the central system that play a double-edged sword role in the progression of senile dementia.This article will elaborate on the impact of aging on microglia,and explore the protective and destructive effects of microglia activation from common diseases such as Alzheimer's disease,vascular dementia,and Parkinson's disease in elderly dementia.A large number of studies have confirmed that traditional Chinese medicine can intervene and improve the progression of senile dementia by regulating microglia,and has the advantages of multiple targets and pathways.
作者
费尔立
顾耘
Erli FEI;Yun GU(Department of Geriatrics,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)
出处
《阿尔茨海默病及相关病杂志》
2024年第4期293-296,303,共5页
Chinese Journal of Alzheimer's Disease and Related Disorders
基金
2022年上海市名老中医学术经验研究工作室建设项目(SHGZS-202241)
基于家庭和社区建立神经认知障碍分级诊疗康复的全程病案管理模式(2017YFC1310501)。
关键词
小胶质细胞
痴呆
中药
衰老
Microglia
Dementia
Traditional chinese medicine
Senility
