摘要
国医大师夏桂成教授立足于中医学天人相应的观点,重视女性生殖节律中的阴阳消长转化,创立“调整月经周期节律法”。女性的特殊生理现象表现在周期节律上,生物钟是产生和调节生物体生理行为和规律的内在机制,生物钟基因广泛表达于卵巢颗粒细胞、卵泡膜细胞及黄体细胞中,并且参与类固醇激素的合成、卵泡体细胞的分化、卵泡发育以及排卵等多个生理过程,在女性生殖内分泌中发挥重要作用。昼夜节律紊乱可导致女性月经失调、卵巢功能障碍、内分泌代谢紊乱等生殖疾病。中医时间医学与生物钟节律系统有共通之处,充分认识生物钟对女性卵巢功能的影响,揭示其科学的内涵,明确其调控方法和机制,对抵御生殖障碍性疾病,优化生育具有积极的促进作用。
Based on the view of the correspondence between nature and man in traditional Chinese medicine(TCM),TCM master Professor Xia Guicheng attaches importance to the transformation of yin and yang in the female reproductive rhythm and created the“menstrual cycle rhythm regulation method”.Women’s special physiological phenomena are manifested in the periodic rhythm.The biological clock is the internal mechanism for producing and regulating the physiological behavior and laws of organisms.The biological clock gene is widely expressed in ovarian granulosa cells,theca cells and corpus luteum cells,and is involved in the synthesis of steroid hormones,differentiation of follicular somatic cells,follicle development and ovulation and other physiological processes,playing an important role in female reproductive endocrine.Circadian rhythm disorders can lead to reproductive diseases such as menstrual disorders,ovarian dysfunction,and endocrine metabolic disorders.There are similarities between TCM time medicine and the biological clock rhythm system.Fully understanding the impact of the biological clock on female ovarian function,revealing its scientific connotation,and clarifying the regulatory method and mechanism will have a positive role in resisting reproductive disorders and optimizing fertility.
作者
谈勇
陈婕
张玉涵
夏桂成
TAN Yong;CHEN Jie;ZHANG Yuhan;XIA Guicheng(The First Clinical Medical College,Nanjing University of Chinese Medicine,Nanjing 210023,China)
出处
《南京中医药大学学报》
CAS
CSCD
北大核心
2024年第10期1080-1086,共7页
Journal of Nanjing University of Traditional Chinese Medicine
基金
国家自然科学基金重点项目(82330125)。
关键词
调周法
生物钟
卵巢功能
女性生殖
menstrual cycle regulation
biological clock
ovarian function
female reproduction
