摘要
目的:探讨艾司氯胺酮联合罗哌卡因对硬膜外阻滞剖宫产产妇的影响。方法:回顾性选取2021年2月—2023年12月湖南省人民医院麻醉科收治的96例硬膜外阻滞剖宫产产妇。根据不同镇痛药物使用将其分为观察组(n=48)和对照组(n=48)。观察组术后给予艾司氯胺酮联合罗哌卡因镇痛,对照组术后给予罗哌卡因镇痛。比较两组术前及术后6 h、12 h、24 h疼痛程度,术前及术后1 d炎症因子及术前(T_(0))、术后6 h(T_(1))、术后12 h(T_(2))、术后24 h(T_(3))血流动力学。结果:术后6 h、12 h、24 h,观察组视觉模拟评分法(VAS)评分低于对照组,差异有统计学意义(P<0.05)。T_(1)、T_(2)、T_(3),两组平均动脉压(MAP)、心率(HR)均低于T_(0),观察组MAP、HR均低于对照组,差异有统计学意义(P<0.05)。术后1 d,两组白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平均高于术前,观察组IL-6、TNF-α水平均低于对照组,差异有统计学意义(P<0.05)。结论:艾司氯胺酮联合罗哌卡因对硬膜外阻滞剖宫产术后镇痛效果较好,能够更有利于稳定血流动力学指标,同时减轻炎症反应。
Objective:To explore the effect of Esketamine combined with Ropivacaine on pregnant women with epidural block cesarean section.Method:A total of 96 pregnant women of epidural block cesarean section in Anesthesiology Department of Hunan Provincial People's Hospital from February 2021 to December 2023 were retrospectively selected.They were divided into observation group(n=48)and control group(n=48)according to the use of different analgesic drugs.The observation group was given Esketamine combined with Ropivacaine analgesia after surgery and the control group was given Ropivacaine analgesia after surgery.The pain degree before surgery and 6 h,12 h and 24 h after surgery,inflammatory factors before and 1 d after surgery and hemodynamics at preoperative(T_(0)),postoperative 6 h(T_(1)),12 h(T_(2)),24 h(T_(3))were compared between the two groups.Result:At 6 h,12 h and 24 h after surgery,the visual analog scale(VAS)scores of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).T_(1),T_(2) and T_(3),the mean arterial pressure(MAP)and heart rate(HR)of the two groups were lower than that in T_(0),and the MAP and HR of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).At 1 d after surgery,the levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the two groups were higher than those before surgery,and the levels of IL-6 and TNF-αin observation group were lower than those in control group,the differences were statistically significant(P<0.05).Conclusion:Esketamine combined with Ropivacaine has better analgesic effect after epidural block cesarean section,which is more conducive to stabilizing hemodynamic indexes and alleviating inflammatory response.
作者
赵雨帆
金琦
ZHAO Yufan;JIN Qi(Hunan Provincial People's Hospital,Changsha 410000,China;不详)
出处
《中外医学研究》
2024年第28期26-29,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
艾司氯胺酮
罗哌卡因
剖宫产
术后镇痛
Esketamine
Ropivacaine
Cesarean section
Postoperative analgesia
