摘要
目的探究加味小柴胡汤联合阿奇霉素应用于小儿支原体肺炎患儿中的临床效果及对中医证候积分、炎症反应的影响。方法102例小儿支原体肺炎患儿,按随机数字表法分为对照组和观察组,每组51例。对照组给予阿奇霉素治疗,观察组在对照组基础上联合加味小柴胡汤治疗。对比两组中医证候积分、临床疗效、炎症指标[C反应蛋白(CRP)、白细胞介素-10(IL-10)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]、不良反应发生情况。结果治疗后,两组发热、咳嗽、气喘、咯痰痰鸣、痰黄粘稠、痰涎壅盛积分均较本组治疗前降低,且观察组发热、咳嗽、气喘、咯痰痰鸣、痰黄粘稠、痰涎壅盛积分分别为(1.13±0.17)、(1.12±0.20)、(0.93±0.15)、(1.05±0.19)、(0.83±0.11)、(1.16±0.12)分,较对照组的(1.89±0.26)、(1.93±0.31)、(1.62±0.19)、(1.68±0.22)、(1.58±0.24)、(1.83±0.15)分低(P<0.05)。观察组治疗总有效率96.08%较对照组的82.35%高(P<0.05)。治疗后,两组CRP、IL-10、IL-6、TNF-α水平均较本组治疗前降低,且观察组CRP、IL-10、IL-6、TNF-α水平分别为(5.69±0.73)mg/L、(13.19±2.56)ng/L、(20.06±1.35)ng/L、(10.75±1.42)μg/L,较对照组的(7.51±0.92)mg/L、(21.06±3.85)ng/L、(23.51±1.87)ng/L、(13.62±1.88)μg/L低(P<0.05)。两组不良反应发生率对比无差异(P>0.05)。结论加味小柴胡汤联合阿奇霉素治疗小儿支原体肺炎患儿效果显著,可有效减轻临床症状、炎症反应,且安全性高。
Objective To explore the clinical effect of modified Xiaochaihu Decoction combined with azithromycin in the treatment of Mycoplasma pneumonia in children and its influence on traditional Chinese medicine syndrome score and inflammatory response in children.Methods 102 children with Mycoplasma pneumonia were randomly divided into a control group and an observation group using a random number table method,with 51 cases in each group.The control group was treated with azithromycin,while the observation group was treated with modified Xiaochaihu Decoction based on the control group.Comparison was made on the traditional Chinese medicine syndrome score,clinical efficacy,inflammatory markers[C-reactive protein(CRP),interleukin-10(IL-10),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],and occurrence of adverse reactions between two groups.Results After treatment,the scores of fever,cough,asthma,sputum and phlegm ringing,phlegm yellow and sticky,and phlegm and saliva congestion in the two groups were lower than those before treatment in this group;the scores of fever,cough,asthma,sputum and phlegm ringing,phlegm yellow and sticky,and phlegm and saliva congestion were(1.13±0.17),(1.12±0.20),(0.93±0.15),(1.05±0.19),(0.83±0.11),and(1.16±0.12)points in the observation group,which were lower than(1.89±0.26),(1.93±0.31),(1.62±0.19),(1.68±0.22),(1.58±0.24),and(1.83±0.15)points in the control group(P<0.05).The total effective rate of treatment of 96.08%in the observation group was higher than 82.35%in the control group(P<0.05).After treatment,the levels of CRP,IL-10,IL-6,and TNF-αin both groups were lower than those before treatment in this group;the CRP,IL-10,IL-6,and TNF-αlevels were(5.69±0.73)mg/L,(13.19±2.56)ng/L,(20.06±1.35)ng/L,and(10.75±1.42)μg/L in the observation group,which were lower than(7.51±0.92)mg/L,(21.06±3.85)ng/L,(23.51±1.87)ng/L,and(13.62±1.88)μg/L in the control group(P<0.05).There was no difference in the comparison of the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of modified Xiaochaihu Decoction and azithromycin shows significant effect on children with Mycoplasma pneumonia,and can effectively alleviate clinical symptoms and inflammatory reactions,and has high safety.
作者
廖贞球
LIAO Zhen-qiu(Pediatrics Department,Ninghua County General Hospital,Sanming 365400,China)
出处
《中国现代药物应用》
2024年第19期16-20,共5页
Chinese Journal of Modern Drug Application
关键词
小儿支原体肺炎
加味小柴胡汤
阿奇霉素
中医证候积分
炎症反应
Mycoplasma pneumonia in children
Modified Xiaochaihu Decoction
Azithromycin
Traditional Chinese medicine syndrome score
Inflammatory response
