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恩格列净联合二甲双胍对2型糖尿病患者的血糖控制水平及胰岛素抵抗指数的影响

Effect of Empagliflozin Combined with Metformin on Blood Glucose Con⁃trol and Insulin Resistance Index in Patients with Type 2 Diabetes Mellitus
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摘要 目的 探讨恩格列净与二甲双胍联合使用对2型糖尿病患者血糖控制水平及胰岛素抵抗指数的影响。方法 选取2022年1月—2023年8月贵州省职工医院收治的110例2型糖尿病患者为研究对象,根据不同的治疗方法分为对照组和观察组,各55例。对照组使用二甲双胍治疗,观察组使用恩格列净联合二甲双胍治疗。比较两组临床效果、血糖水平、血糖变异性指标、胰岛功能指标、血脂水平。结果 观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组空腹血糖、餐后2 h血糖、糖化血红蛋白水平均降低,且观察组低于对照组,差异有统计学意义(P均<0.05)。两组血糖标准差、餐后血糖波动幅度、最大血糖波动幅度均下降,且观察组低于对照组,差异有统计学意义(P均<0.05)。两组患者空腹胰岛素水平、餐后2 h胰岛素水平、胰岛素抵抗指数均降低,且观察组低于对照组,差异有统计学意义(P均<0.05)。治疗后,两组总胆固醇、甘油三酯、低密度脂蛋白胆固醇均降低,高密度脂蛋白胆固醇均升高,且观察组优于对照组,差异有统计学意义(P均<0.05)。结论 2型糖尿病患者使用恩格列净、二甲双胍联合治疗,治疗效果显著,可降低其血糖水平,改善其胰岛功能和血脂水平。 Objective To investigate the effect of combined use of empagliflozin and metformin on blood glucose con-trol and insulin resistance index in patients with type 2 diabetes mellitus.Methods A total of 110 patients with type 2 diabetes admitted to Guizhou Provincial Staff Hospital from January 2022 to August 2023 were selected as the re-search objects.According to different treatment methods,they were divided into control group and observation group,with 55 cases in each group.The control group was treated with metformin,and the observation group was treated with empagliflozin combined with metformin.The clinical effect,blood glucose levels,blood glucose variability indexes,is-let function indexes,blood lipid levels were compared between the two groups.Results The total effective rate of treat-ment of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of fasting blood glucose,2-hour postprandial blood glucose and glycated hemoglo-bin A1c in the two groups decreased,and those in the observation group were lower than the control group,the differ-ences were statistically significant(all P<0.05).After treatment,the standard deviation of blood glucose,postprandial blood glucose fluctuation and maximum blood glucose fluctuation in the two groups decreased,and those in the obser-vation group were lower than the control group,the differences were statistically significant(all P<0.05).After treat-ment,the fasting insulin level,2-hour postprandial insulin level and insulin resistance index of the two groups de-creased,and the observation group was lower than the control group,the difference was statistically significant(all P<0.05).After treatment,the total cholesterol,triglyceride and low density lipoprotein cholesterol in the two group were decreased,and the high density lipoprotein cholesterol was increased,and those in the observation group was better than the control group,the differences were statistically significant(all P<0.05).Conclusion The combination of em-pagliflozin and metformin in patients with type 2 diabetes has a significant therapeutic effect,which can reduce their blood glucose levels and improve their islet function and blood lipid levels.
作者 邹明 黄小娅 朱腾 刘秀美 ZOU Ming;HUANG Xiaoya;ZHU Teng;LIU Xiumei(Department of General Medicine,Guizhou Provincial Staff Hospital,Guiyang 550025,Guizhou,China;Department of General Medicine,Machang Health Hospital,Guiyang 561113,Guizhou,China)
出处 《糖尿病新世界》 2024年第14期13-17,共5页 Diabetes New World
关键词 2型糖尿病 恩格列净 二甲双胍 胰岛素抵抗指数 Type 2 diabetes mellitus Empogliflozin Metformin Insulin resistance index
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