摘要
目的研究甲泼尼龙琥珀酸钠联合阿奇霉素治疗大叶性肺炎患儿的效果及对血清炎性因子水平的影响。方法非随机选取2022年1月—2023年12月沭阳县中医院收治的98例大叶性肺炎患儿为研究对象,按治疗方法分为两组,每组49例。参考组给予阿奇霉素治疗,治疗组给予阿奇霉素联合甲泼尼龙琥珀酸钠治疗。比较两组症状改善时间、肺功能指标、炎症因子指标、治疗总有效率、不良反应。结果治疗组症状改善时间、肺功能指标、炎症因子水平优于参考组,差异有统计学意义(P均<0.05)。治疗组总有效率为97.96%(48/49),高于对照组的83.67%(41/49),差异有统计学意义(χ^(2)=4.405,P<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论采用甲泼尼龙琥珀酸钠联合阿奇霉素联合治疗小儿大叶性肺炎疗效确切,可快速改善患儿症状及肺功能,降低炎症因子水平,安全性高。
Objective To study the effect of methylprednisolone sodium succinate combined with azithromycin in the treatment of children with lobar pneumonia and the effect on serum inflammatory factor levels.Methods Ninety-eight children with lobar pneumonia admitted to Shuyang County Hospital of Traditional Chinese Medicine from January 2022 to December 2023 were non-randomly selected as study subjects,and were divided into two groups according to treatment methods,with forty-nine cases in each group.The reference group was given azithromycin treatment,and the treatment group was given azithromycin combined with methylprednisolone sodium succinate treatment.The two groups were compared in terms of symptom improvement time,lung function indexes,inflammatory factor indexes,to-tal effective rate of treatment,and adverse reactions.Results The symptom improvement time,lung function indexes,and inflammatory factor levels of the treatment group were better than those of the reference group,and the differences were statistically significant(all P<0.05).The total effective rate of the treatment group was 97.96%(48/49),which was higher than 83.67%(41/49)of the reference group,and the difference was statistically significant(χ^(2)=4.405,P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combined treatment of pediatric lobar pneumonia with methylprednisolone sodium succinate combined with azithromycin is efficacious,can rapidly improve the symptoms and lung function of children,reduce the level of inflammatory factors,and is safe.
作者
朱锐
ZHU Rui(Department of Pediatrics,Shuyang Hospital of Traditional Chinese Medicine,Shuyang 223600,Jiangsu,China)
出处
《系统医学》
2024年第17期148-152,共5页
Systems Medicine
关键词
阿奇霉素
甲泼尼龙琥珀酸钠
小儿
大叶性肺炎
炎症因子
肺功能
Azithromycin
Methylprednisolone sodium succinate
Children
Lobar pneumonia
Inflammatory factors
