摘要
目的探讨外周血平均血小板体积(MPV)、血小板与淋巴细胞比值(PLR)、中性粒细胞与淋巴细胞比值(NLR)对晚期结肠癌(CC)患者预后的预测价值。方法选取2018年10月至2021年10月我院收治的68例行CapeOX化疗方案治疗的晚期CC患者,根据化疗后1年的预后情况分为死亡组(n=23)和存活组(n=45),对比两组化疗前的外周血MPV、PLR、NLR,分析外周血MPV、PLR、NLR对晚期CC患者预后的预测价值。结果死亡组的外周血MPV、PLR、NLR均显著高于存活组(P<0.05)。ROC曲线显示,外周血MPV、PLR、NLR联合预测晚期CC患者预后的AUC为0.879,显著高于三者单独预测(P<0.05)。结论外周血MPV、PLR、NLR联合预测晚期CC患者预后的价值较高。
Objective To explore the predictive value of mean platelet volume(MPV),platelet-to-lymphocyte ratio(PLR)and neutrophil-to-lymphocyte ratio(NLR)in peripheral blood for the prognosis of patients with advanced colon cancer(CC).Methods A total of 68 patients with advanced CC treated with CapeOX chemotherapy regimen in our hospital from October 2018 to October 2021 were selected and divided into the death group(n=23)and the survival group(n=45)according to the prognosis at 1 year after chemotherapy.The MPV,PLR and NLR in peripheral blood before chemotherapy were compared between the two groups,and the predictive value of MPV,PLR and NLR in peripheral blood for the prognosis of patients with advanced CC was analyzed.Results The MPV,PLR and NLR in peripheral blood of the death group were significantly higher than those of the survival group(P<0.05).ROC curve showed that the AUC of combined prediction of peripheral blood MPV,PLR and NLR for the prognosis of patients with advanced CC was 0.879,significantly higher than that of single prediction of three indicators(P<0.05).Conclusions The combined prediction of peripheral blood MPV,PLR and NLR for the prognosis of patients with advanced CC has high value.
作者
贾梦荻
袁雯
张肇铱
JIA Mengdi;YUAN Wen;ZHANG Zhaoyi(1^(st)Ward of Oncology Department,the First Affiliated Hospital of He'nan University of Science and Technology,Luoyang 471000,China)
出处
《临床医学工程》
2024年第10期1251-1252,共2页
Clinical Medicine & Engineering
