摘要
目的分析牙周组织再生术与替硝唑联合治疗慢性牙周炎(CP)对患者Notch1 mRNA表达的影响。方法选取丽水市人民医院CP患者130例,根据随机数字表法将其分为对照组(n=65)和观察组(n=65),两组均接受常规治疗,对照组开展牙周组织再生术治疗,观察组开展牙周组织再生术和替硝唑联合治疗,比较两组牙周袋深度(PD)、龈沟出血指数(SBI)、临床附着水平(CAL)、菌斑指数(PLI)的变化,Notch1 mRNA表达、Th17细胞、IL-17水平的变化,以及视觉模拟评分(VAS)、临床疗效、不良反应等。结果治疗后,两组患者PD、SBI、CAL、PLI指数均降低,与对照组相比,观察组PD、SBI、CAL、PLI指数降低更明显,具有统计学差异(P<0.05),治疗后,两组Notch1 mRNA、Th17细胞、IL-17水平均降低,与对照组相比,观察组治疗后Notch1 mRNA、Th17细胞、IL-17水平降低更明显,具有统计学差异(P<0.05),治疗后,两组VAS均有所降低,与对照组相比,观察组VAS降低(P<0.05),与对照组相比,观察组治疗后总有效率高,具有统计学差异(P<0.05),与对照组相比,观察组治疗不良反应略高,但无统计学差异(P>0.05)。结论对CP患者开展牙周组织再生术与替硝唑联合治疗,可降低Notch1 mRNA表达以及疼痛程度,对临床症状治疗效果显著,可以推广使用。
Objective To analyze the effect of periodontal tissue regeneration combined with tinidazole on Notch1 mRNA expression in patients with chronic periodontitis(CP).Methods A total of 130 CP patients from Lishui People's Hospital were selected and randomly divided into control group(n=65)and observation group(n=65)according to random number table method.Both groups received conventional treatment,with the control group receiving periodontal tissue regeneration and the observation group receiving periodontal tissue regeneration combined with tinidazole.The changes in periodontal pocket depth(PD),sulcular bleeding index(SBI),clinical attachment levels(CAL),plaque index(PLI),the levels of Notch1 mRNA expression,Th17 cells and IL-17,Visual Analogue Scale(VAS)score,clinical efficacy,and adverse reactions were compared between the two groups.Results After treatment,the indexes of PD,SBI,CAL and PLI in the two groups were decreased.Compared with the control group,the indexes of PD,SBI,CAL and PLI in the observation group decreased more obviously,with statistical difference(P<0.05).After treatment,the levels of Notch1 mRNA,Th17 cells and IL-17 in both groups were decreased.Compared with the control group,the levels of Notch1 mRNA,Th17 cells and IL-17 in the observation group decreased more significantly after treatment,with statistical difference(P<0.05).After treatment,the VAS scores of the two groups were decreased.Compared with the control group,the VAS scores of the observation group were decreased(P<0.05).After treatment,compared with the control group,the observation group had a higher total effective rate,with statistical difference(P<0.05).Compared with the control group,the adverse reactions of the observation group were slightly higher,but there was no statistical difference(P>0.05).Conclusion The combined treatment of periodontal tissue regeneration and tinidazole in CP patients can reduce Notch1 mRNA expression and pain degree,and has a significant therapeutic effect on clinical symptoms,which can be promoted.
作者
吕俊彬
吴伟栋
张港
LYU Junbin;WU Weidong;ZHANG Gang(Graduate School,Zhejiang Chinese Medical University,Hangzhou 310053,China;Lishui People's Hospital,Lishui 323000,China)
出处
《空军军医大学学报》
CAS
2024年第10期1135-1139,共5页
Journal of Air Force Medical University
基金
浙江省卫生健康科技计划项目(2022KY460)。
