摘要
目的:比较瑞马唑仑与丙泊酚在乳腺癌根治术患者全身麻醉中的应用效果。方法:选取2021年1月至2023年5月该院收治的86例乳腺癌患者进行前瞻性研究,采用随机数字表法将其分为对照组(n=43)与研究组(n=43)。对照组全身麻醉中应用丙泊酚,研究组全身麻醉中应用瑞马唑仑。比较两组麻醉指标(麻醉起效时间、苏醒时间、麻醉恢复室滞留时间)水平、术后苏醒质量[Riker镇静-躁动评分(SAS)、谵妄量表分析系统(CAM-CR)]评分,不同时间[麻醉诱导前5 min(T_(0))、麻醉诱导后5 min(T_(1))、术毕(T_(2))]血流动力学指标[平均动脉压(MAP)、心率]水平,以及不良反应发生率。结果:研究组麻醉起效时间、苏醒时间、麻醉恢复室滞留时间均短于对照组,差异有统计学意义(P<0.05);研究组SAS、CAM-CR评分均低于对照组,差异有统计学意义(P<0.05);T_(1)、T_(2)时,两组MAP、心率水平均低于T_(0)时,但研究组高于对照组,差异有统计学意义(P<0.05);研究组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:瑞马唑仑应用于乳腺癌根治术患者全身麻醉中可改善血流动力学指标水平、术后苏醒质量评分,降低不良反应发生率的效果优于丙泊酚。
Objective:To compare application effects of Remimazolam and Propofol in general anesthesia in patients undergoing radical mastectomy for breast cancer.Methods:A prospective study was conducted on 86 patients with breast cancer admitted to the hospital from January 2021 to May 2023.They were divided into control group(n=43)and study group(n=43)by using the random number table method.Propofol was used in the general anesthesia for the control group,while Remimazolam was used in the general anesthesia for the study group.The levels of anesthesia indexes(onset time of anesthesia,recovery time,residence time in anesthesia recovery room),postoperative recovery quality[sedationagitation scale(SAS),confusion assessment method-Chinese revision(CAM-CR)]and hemodynamic indexes[mean arterial pressure(MAP),heart rate]at different time[5 min before anesthesia induction(T_(0)),5 min after anesthesia induction(T_(1)),end of surgery(T_(2))],and the incidence of adverse reactions were compared between the two groups.Results:The onset time of anesthesia,the recovery time and the residence time in anesthesia recovery room in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).The SAS and CAM-CR scores of the study group were lower than those of the control group,and the differences were statistically significant(P<0.05).At T_(1) and T_(2),the levels of MAP and heart rate in the two groups were lower than those at T_(0),but those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusions:Remimazolam in general anesthesia for the patients undergoing radical mastectomy can improve the levels of hemodynamic indexes,the postoperative recovery quality scores,and reduce the incidence of adverse reactions.Moreover,it is superior to Propofol.
作者
樊少卿
程晓燕
宰晓哲
马浩杰
FAN Shaoqing;CHENG Xiaoyan;ZAI Xiaozhe;MA Haojie(Daytime Operating Room,Henan Provincial Hospital of Traditional Chinese Medicine,The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou,450002 Henan,China)
出处
《中国民康医学》
2024年第20期156-158,共3页
Medical Journal of Chinese People’s Health
关键词
瑞马唑仑
丙泊酚
乳腺癌根治术
全身麻醉
苏醒质量
血流动力学
不良反应
Remimazolam
Propofol
Radical mastectomy for breast cancer
General anesthesia
Recovery quality
Hemodynamics
Adverse reaction
