摘要
目的:观察补肾活血疏肝汤联合西药治疗帕金森病的临床效果。方法:采用随机数字表法将温州市中心医院收治的90例帕金森病患者分为试验组和对照组各45例。对照组予常规西药治疗,试验组在对照组基础上加用补肾活血疏肝汤治疗。比较2组治疗前后中医证候积分及帕金森病氏病综合评分量表(UPDRS)、非运动症状评价量表(NMSE)、汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、匹兹堡睡眠质量指数(PSQI)评分,评估2组临床疗效及不良反应发生情况。结果:试验组总有效率95.56%,高于对照组73.33%(P<0.05)。治疗后,2组中医证候积分及NMSE、UPDRS (UPDRS-Ⅰ、UPDRS-Ⅱ、UPDRS-Ⅲ)、HAMD、HAMA、PSQI评分均低于治疗前(P<0.05),且治疗组上述中医证候积分及各项评分均低于对照组(P<0.05)。试验组不良反应发生率4.44%,低于对照组17.78%(P<0.05)。结论:补肾活血疏肝汤联合西药治疗帕金森病,能够有效提高患者认知功能,改善患者负性情绪和睡眠质量,安全性较高。
Objective:To observe the clinical effect of Bushen Huoxue Shugan Decoction combined with western medicine on Parkinson's disease.Methods:A total of 90 cases of patients with Parkinson's disease admitted to Wenzhou Central Hospital were divided into the trial group and the control group according to the random number table method,with 45 cases in each group.The control group was treated with conventional western medicine,and the trial group was additionally treated with Bushen Huoxue Shugan Decoction based on the treatment of the control group.Traditional Chinese medicine(TCM)syndrome scores,scores of Unified Parkinson's Disease Rating Scale(UPDRS),Non-Motor Symptoms Evaluation(NMSE),Hamilton Depression Scale(HAMD),Hamilton Anxiety Scale(HAMA),and Pittsburgh Sleep Quality Index(PSQI)were compared between the two groups before and after treatment.Clinical effects and the incidence of adverse reactions were evaluated in the two groups.Results:The total treatment effective rate was 95.56%in the trial group,which was higher than that of 73.33%in the control group(P<0.05).After treatment,TCM syndrome scores,as well as the scores of NMSE,UPDRS(UPDRS-Ⅰ,UPDRS-Ⅱ,UPDRS-Ⅲ),HAMD,HAMA,and PSQI in the two groups were lower than those before treatment(P<0.05),and the TCM syndrome scores and other scores in the trial group were lower than those in the control group(P<0.05).The incidence of adverse reactions was 4.44%in the trial group,which was lower than that of 17.78%in the control group(P<0.05).Conclusion:Bushen Huoxue Shugan Decoction combined with western medicine for Parkinson's disease can effectively improve patients'cognitive function,negative emotions,and quality of sleep,with high safety.
作者
吴晓丹
肖萌
翁陈怡
WU Xiaodan;XIAO Meng;WENG Chenyi(Department of General Internal Medicine,Wenzhou Central Hospital,Wenzhou Zhejiang 325000,China)
出处
《新中医》
CAS
2024年第20期48-52,共5页
New Chinese Medicine
关键词
帕金森病
补肾活血疏肝汤
负性情绪
睡眠质量
Parkinson's disease
Bushen Huoxue Shugan Decoction
Negative emotions
Quality of sleep
