摘要
目的分析血常规检验在缺铁性贫血(IDA)和地中海贫血(TM)患者中的应用及检测准确性。方法选择上杭县医院2023年2月—2024年1月收治的100例贫血患者作为研究对象,根据贫血类型分为IDA组(55例)和TM组(45例)。采用全自动血液分析仪检测血常规指标〔红细胞计数(RBC)、白细胞计数(WBC)、红细胞分布宽度(RDW)、平均红细胞体积(MCV)、平均血小板体积(MPV)、血红蛋白(Hb)、平均红细胞血红蛋白浓度(MCHC)、平均红细胞血红蛋白量(MCH)、网织红细胞血红蛋白含量(RET-He)〕;比较两组上述指标水平差异。使用多因素Logistic回归分析鉴别诊断IDA和TM的独立影响因素;绘制受试者工作特征曲线(ROC曲线)并计算ROC曲线下面积(AUC),评估血常规指标鉴别贫血类型的效能。结果IDA组的RBC、RDW、MCV、RET-He水平均显著高于TM组,Hb、MCHC水平均显著低于TM组〔RBC(×10^(12)/L):4.64±1.15比2.79±0.81;RDW:(18.36±1.79)%比(12.23±1.48)%;MCV(fL):74.68±2.47比66.89±2.42;RET-He(pg):20.43±5.62比15.93±5.38;Hb(g/L):81.41±12.07比107.65±12.41;MCHC(g/L):310.56±13.41比321.45±14.68;均P<0.05〕。Logistic回归分析结果显示,RDW、MCV、Hb均为诊断鉴别IDA和TM的独立影响因素,AUC分别为0.840、0.836、0.855,三者联合检测的AUC为0.915,敏感度和特异度分别为88.58%、90.02%。结论对IDA和TM患者进行血常规检验有助于鉴别IDA和TM,诊断准确度较高。
Objective To analyze the application and accuracy of blood routine test in patients with iron deficiency anemia(IDA)and thalassemia(TM).Methods A total of 100 patients with anemia admitted to Shanghang County Hospital from February 2023 to January 2024 were selected as study subjects.They were divided into IDA group(55 cases)and TM group(45 cases)according to type of anemia.Blood routine indicators[red blood cell count(RBC),white blood cell count(WBC),red blood cell distribution width(RDW),mean corpuscular volume(MCV),mean platelet volume(MPV),hemoglobin(Hb),mean corpuscular hemoglobin concentration(MCHC),mean corpuscular hemoglobin(MCH)and reticulocyte hemoglobin equivalent(RET-He)]were detected using fully automatic hematology analyzer.Above indicators were compared between the two groups.Multivariate Logistic regression analysis was conducted to identify the independent influencing factors for differential diagnosis of IDA and TM.Receiver operator characteristic curve(ROC curve)was plotted,and the area under ROC curve(AUC)was calculated to evaluate the clinical diagnostic efficacy of blood routine indicators for type of anemia.Results The levels of RBC,RDW,MCV and RET-He in IDA group were higher than those in TM group,and the levels of Hb and MCHC were lower than those in TM group[RBC(×10^(12)/L):4.64±1.15 vs.2.79±0.81;RDW:(18.36±1.79)%vs.(12.23±1.48)%;MCV(fL):74.68±2.47 vs.66.89±2.42;RET-He(pg):20.43±5.62 vs.15.93±5.38;Hb(g/L):81.41±12.07 vs.107.65±12.41;MCHC(g/L):310.56±13.41 vs.321.45±14.68;all P<0.05].Logistic regression analysis results showed that RDW,MCV and Hb were independent influencing factors for differential diagnosis of IDA and TM,and the AUC values were 0.840,0.836 and 0.855.The AUC of combination of three indicators was 0.915,and the sensitivity and specificity were 88.58%and 90.02%.Conclusion Blood routine test is beneficial to distinguish IDA and TM,and the diagnostic accuracy is high.
作者
邓慧英
谢劲
Deng Huiying;Xie Jin(Department of Clinical Laboratory,Shanghang County Hospital,Longyan 364200,Fujian,China;Department of Emergency,Shanghang County Hospital,Longyan 364200,Fujian,China)
出处
《实用检验医师杂志》
2024年第3期254-256,共3页
Chinese Journal of Clinical Pathologist
