摘要
背景:弥漫性特发性骨肥厚症是一种以韧带、肌腱等软组织及其附着部位的钙化和骨化为主要表现的全身性非炎症疾病,主要影响50岁以上的男性。研究表明肥胖症患者中弥漫性特发性骨肥厚症的发病率更高,但二者的因果关系尚不明确。目的:旨在通过孟德尔随机化分析方法,探讨肥胖症与弥漫性特发性骨肥厚症之间的因果关系。方法:研究选取全基因组关联研究数据库中的单核苷酸多态性作为工具变量,包括肥胖症和弥漫性特发性骨肥厚症相关数据。使用双向双样本孟德尔随机化分析方法评估肥胖症与弥漫性特发性骨肥厚症之间的因果关系,同时进行多效性、异质性和敏感性评价。结果与结论:孟德尔随机化分析发现肥胖症与弥漫性特发性骨肥厚症之间存在显著的正向因果关系。逆方差加权法显示“肥胖”(OR=1.111,95%CI:1.068-1.156,P=1.598×10^(-7))、“肥胖,热量过剩”(OR=1.093,95%CI:1.042-1.146,P=0.000)和“肥胖,其他/不详”(OR=1.109,95%CI:1.069-1.152,P=4.908×10^(-8))均与弥漫性特发性骨肥厚症显著相关。反向孟德尔随机化分析未发现弥漫性特发性骨肥厚症与肥胖症之间存在因果关系。多效性、异质性和敏感性检验结果验证了孟德尔随机化分析结果的可靠性。这表明肥胖症显著增加了弥漫性特发性骨肥厚症的风险,但弥漫性特发性骨肥厚症并不是肥胖症的危险因素。
BACKGROUND:Diffuse idiopathic skeletal hyperostosis is a systemic,non-inflammatory disease characterized by calcification and ossification of ligaments,tendons,and their attachments,predominantly affecting men over the age of 50.Studies have shown a higher prevalence of diffuse idiopathic skeletal hyperostosis among obese individuals;however,the causal relationship between the two remains unclear.OBJECTIVE:To investigate the causal relationship between obesity and diffuse idiopathic skeletal hyperostosis using Mendelian randomization analysis.METHODS:The study utilized single nucleotide polymorphisms from the Genome Wide Association Study database as instrumental variables,incorporating data related to obesity and diffuse idiopathic skeletal hyperostosis.A bidirectional two-sample Mendelian randomization analysis was performed to assess the causal relationship between obesity and diffuse idiopathic skeletal hyperostosis,with evaluations for pleiotropy,heterogeneity,and sensitivity.RESULTS AND CONCLUSION:The Mendelian randomization analysis revealed a significant positive causal relationship between obesity and diffuse idiopathic skeletal hyperostosis.The inverse-variance weighted method indicated that“obesity”(odds ratio[OR]=1.111,95%confidence interval[CI]:1.068-1.156,P=1.598×10^(-7)),“obesity due to excess calories”(OR=1.093,95%CI:1.042-1.146,P=0.000),and“obesity,other/unspecified”(OR=1.109,95%CI:1.069-1.152,P=4.908×10^(-8))were significantly associated with diffuse idiopathic skeletal hyperostosis.Conversely,the reverse Mendelian randomization analysis did not find a causal relationship between diffuse idiopathic skeletal hyperostosis and obesity.The robustness of the Mendelian randomization analysis results was confirmed by pleiotropy,heterogeneity and sensitivity tests,indicating that while obesity significantly increases the risk of diffuse idiopathic skeletal hyperostosis,but diffuse idiopathic skeletal hyperostosis does not pose a risk factor for obesity.
作者
孔鹿鸣
赵弟乾
白文哲
李念虎
Kong Luming;Zhao Diqian;Bai Wenzhe;Li Nianhu(The First Clinical Medical School,Shandong University of Traditional Chinese Medicine,Jinan 250014,Shandong Province,China;Shandong University of Traditional Chinese Medicine Affiliated Hospital,Jinan 250014,Shandong Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2025年第17期3705-3712,共8页
Chinese Journal of Tissue Engineering Research
基金
山东省自然科学基金项目(ZR2023MH063),项目负责人:李念虎
徐展望全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号),项目负责人:李念虎。
关键词
弥漫性特发性骨肥厚症
肥胖症
代谢综合征
孟德尔随机化
单核苷酸多态性
工具变量
因果关系
工程化骨组织
diffuse idiopathic skeletal hyperostosis
obesity
metabolic syndrome
Mendelian randomization
single nucleotide polymorphisms
instrumental variables
causality
engineered bone tissue
