摘要
目的:研究股骨头坏死(ONFH)患者股骨头内骨囊性变与血清Ⅰ型胶原羧基端肽β交联肽(β-CTx)的关系。方法:收集2023年5月至2023年12月收治住院的股骨头坏死患者共180例263髋,根据患者X线片和CT影像上有无骨囊性变,将患者分为囊性变组和非囊性变组,对比两组患者血液β-CTx水平差异。结果:囊性变组86例,男63例,女23例;平均年龄为(40.84±12.72)岁,平均病程为(7.85±2.47)个月。非囊性变组94例,男64例,女30例;平均年龄为(44.09±12.85)岁,平均病程为(7.85±3.15)个月。囊性变组患者血清β-CTx水平为(0.86±0.37)ng/mL,显著高于非囊性变组的(0.52±0.20)ng/mL,差异有统计学意义(F=26.631,P<0.001)。结论:股骨头坏死合并骨囊性变患者血清β-CTx显著高于无囊性变患者,提示骨的快速吸收可能是促使骨囊性变发生的重要原因之一。
Objective:To investigate the relationship between bone cystic degeneration of femoral head and serum β-CTx of type Ⅰ collagen in patients with osteonecrosis of the femoral head(ONFH).Methods:A total of 263 hips of 180 patients with ONFH who were admitted from May 2023 to December 2023 were collected.According to the presence or absence of bone cystic degeneration on X-ray and CT images,the patients were divided into cystic degeneration group and non-cystic degeneration group,and the differences in blood β-CTx levels between the two groups were compared.Results:There were 86 patients in the cystic degeneration group,63 males and 23 females,with(40.84±12.72) years old on average and an average course of(7.85±2.47) months.There were 94 patients in the non-cystic degeneration group,64 males and 30 females,with an average age of(44.09±12.85) years old and an average course of(7.85±3.15) months.Serum β-CTx in patients with cystic degeneration(0.86±0.37) ng/mL was significantly higher than that in patients without cystic degeneration(0.52±0.20) ng/mL,and the difference was statistically significant(F=26.631,P<0.001).Conclusion:Serum β-CTx level was significantly higher in patients with osteonecrosis combined with bone cystic degeneration than in patients without bone cystic degeneration,suggesting that rapid bone resorption may be one of the important reasons for the occurrence of bone cystic degeneration.
作者
任之强
阎晓霞
赵志强
吴秀丽
李龙飞
李金菊
REN Zhiqiang;YAN Xiaoxia;ZHAO Zhiqiang;WU Xiuli;LI Longfei;LI Jinju(Luoyang Orthopedic-Traumatological Hospital of Henan Province(Henan Provincial Orthopedic Hospital),Zhengzhou 450046,China;Henan University of Chinese Medicine,Zhengzhou 450046,China)
出处
《中国中医骨伤科杂志》
CAS
2024年第10期50-53,59,共5页
Chinese Journal of Traditional Medical Traumatology & Orthopedics
基金
河南省科技攻关项目(232102310423)
河南省中医药科学研究专项课题(2024ZY2108,2024ZY2115)。
关键词
股骨头坏死
骨囊性变
Ⅰ型胶原羧基端肽β交联肽
osteonecrosis of femoral head
bone cystic degeneration
β-CTx of type I collagen
